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US Patent 5886023 - Agent for improving dementia

US Patent Issued on March 23, 1999
Estimated Patent Expiration Date: Icon_subject March 23, 2016Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The present invention aims at providing a drug which is highly effective in improving decline of mental functions such as disorientation, which are the major symptoms of dementia such as Alzheimer type dementia or cerebrovascular dementia, as well as general side symptoms such as decreased spontaneity, contact disturbances, motivation, emotional disturbances, abnormal behaviors and disturbances in activity of daily living. The agent for improving dementia of the present invention comprises N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide or a salt thereof as an active ingredient.

Other References

  • Oslo et al "Remington's Pharmaceutical Sciences" (1980) pp. 1554-1557
  • Handbook of Pharmaceutical Excipients (1986) pp. 134-137
  • Advances in Behavioral Biology, vol. 38B, 1990, pp. 367-370; H. Kojima et al.: "Effect of DM-9384, A New Pyrrolidone Derivative, on Passive Avoidance and Cerebral Choline Acetyltransferase Activity in Rats"
  • Advances in Behavioral Biology, vol. 38B, 1990, pp. 371-374; T. Kameyama et al.: "DM-9384, A Pyrrolidone Derivative, Ameliorates Basal Forebrain Lesion-induced Amnesia and Inhibits Cycloheximide-induced Decrease in the Number of GABA and Acetylcholine Receptors"
  • Advances in Alzhimer Disease Therapy Series, 1991, pp. 337-344, (editors R. Becker et al.), Birkhauser, Boston, Mass., US, M. Yoshida: "alzheimer Therapy with Cholinomimetics: Japanese Experience"
  • Pharmacology Biochemistry & Behavior, vol. 36, No. 2, 1990, pp. 233-236, Pergamon Press Plc, US; T. Nabeshima et al.: "Effects of DM-9382, a Pyrrolidone Derivative, on Alcohol-and Chlordiazepoxide-induced Amnesia in Mice"
  • Advances in Behavioral Biology, vol. 38A, 1990, pp. 735-738; C. Hara et al.: "Characteristics of Learning Deficit Induced by Ibotenic Acid Lesion of the Frontal Cortex Related with the Nucleus Basalis of Meynert in Rats"

Inventors

Assignee

Application

No. 447054 filed on 05/22/1995

US Classes:

514/424Chalcogen bonded directly to the five-membered hetero ring by nonionic bonding

Field of Search

514/424Chalcogen bonded directly to the five-membered hetero ring by nonionic bonding

Examiners

Primary: Henley, III, Raymond

Attorney, Agent or Firm

US Patent References

4341790, Pyrrolidinylalkylcarboxylic acid amide derivatives, their preparation and pharmaceutical compositions containing them
Issued on: 07/27/1982
Inventor: Betzing ,   et al.
4385053Treatment for human memory impairment associated with aging
Issued on: 05/24/1983
Inventor: Reisberg ,   et al.

Foreign Patent References

  • 0314275 EP 05/20/1989
  • 0408524 EP 01/20/1991
  • 2382441 FR 09/20/1978
  • 2053909 GB 02/20/1981

International Class

A61K 031/40

Foreign Application Priority Data

1991-05-02 JP

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