Patent ReferencesControlled absorption diltiazem formulation for once-daily administration Controlled release formulation for pharmaceutical compounds Diltiazem formulation Multilayered controlled release pharmaceutical dosage form Patent #: 5474786 InventorsApplicationNo. 912722 filed on 08/18/1997US Classes:424/472, Layered unitary dosage forms424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/490, Coated (e.g., microcapsules)424/494, Cellulose derivatives424/495, Ethyl cellulose424/497Containing solid synthetic polymersExaminersPrimary: Page, Thurman K.Assistant: Seidleck, Brian K. Attorney, Agent or FirmInternational ClassA61K 009/24AbstractA single bead drug delivery system suitable for oral administration with multiply layered drug and polymer compartments can provide a two-step release of active agent to facilitate an immediate yet sustained drug delivery over a 24 hour period following oral administration with minimized variance between peak and trough levels of therapeutic drug amounts.Other References
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