U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Sustained release drug delivery system suitable for oral administration

Patent 5885616 Issued on March 23, 1999. Estimated Expiration Date: Icon_subject August 18, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Controlled absorption diltiazem formulation for once-daily administration
Patent #: 4894240
Issued on: 01/16/1990
Inventor: Geoghegan, et al.

Controlled release formulation for pharmaceutical compounds
Patent #: 5320853
Issued on: 06/14/1994
Inventor: Noda, et al.

Diltiazem formulation
Patent #: 5439689
Issued on: 08/08/1995
Inventor: Hendrickson, et al.

Multilayered controlled release pharmaceutical dosage form Patent #: 5474786
Issued on: 12/12/1995
Inventor: Kotwal, et al.

Inventors

Application

No. 912722 filed on 08/18/1997

US Classes:

424/472, Layered unitary dosage forms424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/490, Coated (e.g., microcapsules)424/494, Cellulose derivatives424/495, Ethyl cellulose424/497Containing solid synthetic polymers

Examiners

Primary: Page, Thurman K.
Assistant: Seidleck, Brian K.

Attorney, Agent or Firm

International Class

A61K 009/24

Abstract

A single bead drug delivery system suitable for oral administration with multiply layered drug and polymer compartments can provide a two-step release of active agent to facilitate an immediate yet sustained drug delivery over a 24 hour period following oral administration with minimized variance between peak and trough levels of therapeutic drug amounts.

Other References

  • {711} Dissolution; USP 23; Physical Tests {711} 1791-1794, 2185,3208-3209, 2577-2578, 3794-3495, 2833-2834
  • {724} Drug Release; USP 23; Physical Tests 1793-1799,2534-2536, 2709-2715, 3012-3017, 3209-3215, 3468-347
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