Patent 5885585 Issued on March 23, 1999. Estimated Expiration Date: May 15, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/204.1, Virus or component thereof424/186.1, Disclosed amino acid sequence derived from virus435/235.1, VIRUS OR BACTERIOPHAGE, EXCEPT FOR VIRAL VECTOR OR BACTERIOPHAGE VECTOR; COMPOSITION THEREOF; PREPARATION OR PURIFICATION THEREOF; PRODUCTION OF VIRAL SUBUNITS; MEDIA FOR PROPAGATING435/236, Inactivation or attenuation; producing viral subunits536/23.72Viral protein
The invention is directed to attenuated canine parvovirus (CPV) strains which may be used as a veterinary vaccine against CPV disease. The invention is further directed to a virus stock generated from a genomic DNA clone of the attenuated CPV strain which is used as a veterinary vaccine and is able to confer protective immunity to dogs against challenge with virulent CPV. Methods are given for the production of an attenuated CPV virus from a cloned CPV genome which may be used as a veterinary vaccine.
Other References
Parrish et al., Rapid Antigen-Type Replacement and DNA Sequence Evolution of Canine Parvovirus, J. Virol., vol. 65, No. 12, pp. 6544-6552, see p. 6545, left column , p. 6544, column 2, second full paragraph), Dec. 1991
Parrish, Emergence, Natural History, and Variation of Canine, Mink, and Feline Parvoviruses, Adv. Virus Res. 38:403-450, see pp. 419-423, 1990
Gruenberg et al., 1993, "Preparation and analysis of a molecular clone of an attenuated strain of canine parvovirus" Abstract, 5th Parvovirus Workshop, Nov. 10-14, 1993, Cyrstal River, Florida
Lopez de Turison et al., 1992, "Recombinant vaccine for canine parvovirus in dogs", J Virol 66(5):2748-2753
Saliki et al., 1992, "Canine parvovirus empty capsids produced by expression in a baculovirus vector: Use in analysis of viral properties and immunization of dogs", J Gen Virol 73:369-374
Parrish et al., 1991 "Mapping specific functions in the capsid structure of canine parvovirus and feline panleukipenia virus using infectious plasmid clones", Virology 183:195-205
Parrish et al., 1991, "Rapid antigenic-type replacement and DNA sequence evolution of canine parvovirus", J Virol 65(12):6544-6552
Parrish, 1990, "Emergence, natural history, and variation of canine, mink, and feline parvovirus", Adv Virus Res 38:403-450
Ausubel et al., 1989, Current Potocols in Molecular Biology, Greene Publshing Associates and Wiley Interscience, Chapter 8
Chang et al., 1988, "Multiple amino acids in the capsid structure of canine parvovirus coordinately determine the canine host range and specific antigenic and hemagglutination properties", J Virol 66(12):6858-6867
Mazzara et al., 1987, "Successful vaccination of dogs with empty capsids derived from canine parvovirus-bovine papillomavirus chimeric plasmids", Vaccines 87, Cold Spring Harbor Laboratory Press, pp. 419-424
Botstein and Shortle, 1985, "Strategies and applications of in vitro mutagenesis", Science 229:1193-1201
Parrish et al., 1984, "Characterization of antigenic variation among mink enteritis virus isolates", Am J Vet Res 45:2591-2599
Zoller and Smith, 1984, "Oligonucleotide-directed mutagenesis: A simple method using two oligonucliotide primers and a single stranded DNA template", DNA 3(6):479-488
Carmichael et al., 1983, "A modified live canine parvovirus vaccine II. Immune Response", Cornell Vet 73:13-29
Carmichael et al. 19881, "A modified live canine parvovirus strain with novel plaque characteristics I. Viral attenuation and dog response", Cornell Vet 71:408-427
Carmichael et al., 1980 "Hemagglutination by canine parvovirus: Serologic studies and diagnostic applications", Am J Vet Res 41(5):784-791
Appel et al., 1979, "Isolation and immunisation studies of a canine parvo-like virus from dogs with haemorrhagic enteritis", Vet Record 105:156-159
Bovarnick et al., 1950, "The influence of certain salts, amino acids, sugars, and proteins on the stability of rickettsiae", J Bact 59:509-522
Gruenberg et al., 1993, Poster Panels from an oral presentation given at the Fifth Parvovirus Workshop, Crystal City, Florida, Nov. 10-14, 1993
Churchill, 1987, "Preliminary Devleopment of a Live Attenuated Canine Parvovirus Vaccine from an isloate of British origin", The Veterinary Record 120:334-33