Method for treating the internal urinary bladder and associated structures using hyaluronic acid

Patent 5880108 Issued on March 9, 1999. Estimated Expiration Date:

March 26, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Therapeutic dimethyl sulfoxide composition and methods of use
Patent #: 4296104
Issued on: 10/20/1981
Inventor: Herschler

Process for preparing CSA or CSC
Patent #: 4302577
Issued on: 11/24/1981
Inventor: Rucker

Process for the preparation of injectable chondroitin polysulfate
Patent #: 4524066
Issued on: 06/18/1985
Inventor: Wolf

Administration of "active" chondroitin sulfate A and "active" chondroitin sulfate C or mixtures thereof to mammals including humans
Patent #: 4640912
Issued on: 02/03/1987
Inventor: Hausman

Composition and process for promoting epithelial regeneration
Patent #: 4711780
Issued on: 12/08/1987
Inventor: Fahim

Method and composition for arresting angiogenesis and capillary, cell or membrane leakage
Patent #: 4820693
Issued on: 04/11/1989
Inventor: Gillespie

Medical application for heparin and related molecules
Patent #: 4879282
Issued on: 11/07/1989
Inventor: Saliba, Jr.

Method and composition for arresting angiogenesis and capillary, cell or membrane leakage
Patent #: 4966890
Issued on: 10/30/1990
Inventor: Gillespie

Medical application for heparin and related molecules
Patent #: 5037810
Issued on: 08/06/1991
Inventor: Saliba, Jr.

Irrigation of internal bladder surfaces in mammals with sodium pentosanpolysulfate Patent #: 5180715
Issued on: 01/19/1993
Inventor: Parsons

Inventors

Assignee

Bioniche, Inc.

Application

No. 824890 filed on 03/26/1997

US Classes:

514/54Polysaccharide

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

Jones & Askew

International Classes

A61K 031/70
A61K 031/725

Abstract

A method of treating cystitis comprising contacting the urinary bladder and associated structures in a mammal having cystitis with a solution containing hyaluronic acid having a average molecular weight of not less than 2×105 Daltons in a concentration effective to treat the cystitis. The solution may further contain an agent effective to treat the associated cause of the cystitis in a concentration effective to treat the associated cause of the cystitis.

Other References

Stewart et al., "The Use of Dimethyl Sulfoxide (DMSO) in the Treatment of Interstitial Cystitis," J. Urology, vol. 98, pp. 671-672 (1968)
Parsons et al., "Decreased Urinary Uronic Acid Levels in Individuals with Interstitial Cystitis," J. Urology, vol. 143, pp. 690-693 (1990)
Fleischmann et al., "Clinical and Immunological Response to Nifedipine for the Treatment of Interstitial Cystitis," J. Urology, vol. 146, pp. 1235-1239 (1991)
Nickel et al., "The Bladder Mucus (Glycosaminoglycan) Layer in Interstitial Cystitis," J. Urology, vol. 149, pp.716-718 (1993)
Hanno et al., "Conservative Therapy of Interstitial Cystitial," Seminars in Urology, vol. 9, No. 2, pp. 143-147 (1991)
Chelsky et al., "Bladder Permeability in Interstitial Cystitis is Similar to that of Normal Volunteers: Direct Measurement by Transvesical Absorption of 99m Technetiumdiethylenetriaminepentaacetic Acid," J. Urology, vol. 151, pp. 346-349 (1994)
Eldrup et al., "Permeability and Ultrastructure of Human Bladder Epithelium," Br. J. Urology, vol. 55, pp. 488-492 (1983)
Brandt, "The Effect of Synovial Hyaluronate on the Injestion of Monosodium Urate Crystals by Leukocytes," Clinica Chimica Acta, vol. 55, pp. 307-315 (1974)
Messing et al., "Interstitial Cystitis," Urology, vol. 12, No. 4 pp. 381-392 (1978)
Balazs et al., "The Effect of Hyaluronic Acid on Fibroblasts, Mononuclear Phagocytes and Lymphocytes," Biology of Fibroblasts, Academic Press, pp. 237-252 (1973)
Kuwahara et al., "Bacterial Infection and Acid Mucopolysaccharides in Epithelium of Rat Urinary Bladder," Urological Research, vol. 10, No. 2, pp. 93-96 (1982