Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers
May 5, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesTreatment for periodontal disease Treatment for tissue degenerative inflammatory disease Method for accelerated wound healing Method for the treatment of aging or photo-damaged skin Method and compositions for topical application to the skin for prevention and/or treatment of radiation-induced skin damage Method and compositions for treatment and/or prevention of skin damage and aging Patent #: 5554647 InventorApplicationNo. 851222 filed on 05/05/1997US Classes:424/401, Cosmetic, antiperspirant, dentifrice514/944GELExaminersPrimary: Venkat, JyothsnaAttorney, Agent or FirmInternational ClassA61K 007/48AbstractCompositions for the topical treatment of sagging subcutaneous muscle and overlying cutaneous tissue contain an active ingredient exhibiting or producing catecholamine activity such as catecholamines and/or related compounds in a dermatologically acceptable carrier that contains at least one percutaneous penetration enhancer. Examplary catecholamines include adrenaline, norepinepherine, dopamine and their precursors; catecholamine precursors such as tyrosine and phenylalanine are preferred. Many embodiments, particularly those employing tyrosine and/or phenylalanine as a catecholamine precursor, further contain a neurotransmitter synthesis enhancer such as dimethylaminoethanol, and other co-factors such as vitamin B6 and pantothenic acid or calcium pantothenate are included in the composition to enhance the action of the active ingredients. Other compounds that scavenge free radicals and antioxidants may also be added.Other References
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