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Encrustation and bacterial resistant coatings for medical applications

Patent 5877243 Issued on March 2, 1999. Estimated Expiration Date: Icon_subject May 5, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3798750

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Indwelling urethral catheter system and method
Patent #: 4946449
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Patent #: 4950256
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Urinary catheter and system
Patent #: 5295979
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Inventor: DeLaurentis, et al.

Iontophoretic structure for medical devices
Patent #: 5322520
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Encrusting and bacterial resistant coatings for medical applications Patent #: 5328954
Issued on: 07/12/1994
Inventor: Sarangapani

Inventor

Assignee

Application

No. 851306 filed on 05/05/1997

US Classes:

524/139, Phosphorus directly bonded to at least one O and at least one H or C only523/105, Nonmedicated composition specifically intended for contact with living animal tissue or process of preparing; other than apparel524/239, Two or more (C=X)X groups524/291, OH group other than as part of a COOH group, e.g., salicylic acid, etc.524/310, OH group other than as part of a COOH group, e.g., castor oil, etc.524/403, At least one element of the lanthanide series (atomic no.57-71) or contains a noble metal atom (i.e., Au, Ag, Hg, Pt, Pd, Ir, Rh, Ru, Os)DNRM524/413, Transition metal other than Group VIII DNRM (i.e., Sc, Ti, Mn, Cu, Y, Zr, Tc, Hf, Re)524/589, From -N=C=X reactant or blocked N=C=X reactant (X is chalcogen)524/590, With reactant containing at least one C-OH, (C=O)-OH or -C-O-C- group524/871, N=C=X containing reactant forming a solid polymer or SICP in the presence of a nonreactant material (X is chalcogen)524/874With N-containing reactant

Examiners

Primary: Morgan, Kriellion S.

Attorney, Agent or Firm

International Classes

C08K 003/10
C08K 005/10
C08K 005/09
C08K 005/51

Abstract

Disclosed are coatings and materials that resist bacterial colonization and encrustation for use in medical devices and urological applications. The coating includes acidic chelating components, reactively bound to a hydrophilic polyurethane prepolymer along with noble metal combinations or antibacterials. The acidic and noble metal combinations can also be incorporated as additives during plastic molding of medical devices. A continuous antibacterial surfaces are provided by such coatings and materials.

Other References

  • Johnson, J.R. et al., "Prevention of Catheter-Associated Urinary Tract Infection with a Silver Oxide-Coated Catheter: Clinical and Microbiologic Correlates," The Journal of Infectious Diseases 1990; 162:1145-1150
  • Liedberg et al., "Silver Alloy Coated Catheters Reduce Catheter-associated Bacteriuria," British Journal of Urology (1990) 65:379-381
  • McLean, R.J.C. et al., "Antibacterial activity of multilayer silver-copper surface films on catheter material," Can. J. Microbiol. vol. 39, 1993, 895-899
  • McLean, R.J.C. et al., "A simple technique for studying struvite crystal growth in vitro," Urological Research (1990) 18:39-43
  • Nickel, J.C. et al., "Tobramycin Resistance of Pseudomonas aeruginosa Cells Growing as a Biofilm on Urinary Catheter Material," Antimicrobial Agents and Chemotherapy, Apr. 1985, vol. 24, No. 4, pp. 619-624
  • Sarangapani, S. et al., "An improved model for bacterial encrustation studies," Journal of Biomedical Materials Research, vol. 29, 1185-1191 (1995)
  • Schaeffer, A.J. et al., "Effect of Silver Oxide/Trichloroisocyanuric Acid Antimicrobial Urinary Drainage System on Catheter-Associated Bacteriuria," The Journal of Urology, vol. 139, January, pp. 69-73
  • Webb, C.L. et al., "Aminodiphosphate or AI+++ Preincubation Inhibits Calcification of Aortic Homografts in the Rat Subdermal Model," vol. XXXIV Trans Am Soc Artif Intern Organs 1988, pp. 851-85
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