U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Dry powder inhaler

Patent 5875776 Issued on March 2, 1999. Estimated Expiration Date: Icon_subject April 9, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

1642950

2147158

3425414

3739950

3856142

Inhalation device
Patent #: 4509515
Issued on: 04/09/1985
Inventor: Altounyan ,   et al.

Collapsible inhalation valve
Patent #: 4796614
Issued on: 01/10/1989
Inventor: Nowacki ,   et al.

Continuous sonication method for preparing protein encapsulated microbubbles
Patent #: 4957656
Issued on: 09/18/1990
Inventor: Cerny, et al.

Disposable powder medicament inhalation device with peel-off cover
Patent #: 5239991
Issued on: 08/31/1993
Inventor: Chawla, et al.

Apparatus and method for ionizing medication containing mists
Patent #: 5267555
Issued on: 12/07/1993
Inventor: Pajalich

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Inventor

Assignee

Application

No. 629605 filed on 04/09/1996

US Classes:

128/203.15, Particulate treating agent carried by breathed gas128/203.12, Means for mixing treating agent with respiratory gas128/203.21Means broken or pierced to supply treating agent

Examiners

Primary: Lewis, Aaron J.

Attorney, Agent or Firm

Foreign Patent References

  • 0 634 184 A1 EP. 01/13/1995
  • WO 91/16038 WO. 10/13/1991
  • WO 93/00951 WO. 01/13/1993
  • WO 94/08552 WO. 04/13/1994
  • WO 94/23772 WO. 10/13/1994
  • WO 95/07724 WO. 03/13/1995
  • WO 95/11666 WO. 05/13/1995
  • WO 95/11715 WO. 05/13/1995

International Class

A61M 015/00

Abstract

A dry powder inhaler includes a housing, a dosing cartridge, and a spacer. Within the housing are a source of pressurized gas, a pressure gauge, a metered valve controlled by a trigger, a safety valve, and an electrostatic charger also controlled by the trigger. The dosing cartridge contains individual doses in airtight cells with one or more openings, each covered by an airtight coversheet. The system uses gas pressure or a penetration device to rupture one of the airtight cells, suspending the powder and directing it to a spacer for subsequent inhalation. The electrostatic charger discharges on the spacer, establishing an electrostatic charge thereon. The spacer includes a non-stick lining. The housing is designed so that it can retract into the spacer.

Other References

  • Barnes, Peter J., "Inhaled Glucocorticoids For Asthma." The New England Journal of Medincine 322 (13): 868-875 (1995)
  • Bell et al., "Dry Powder Aerosols I: A New Powder Inhalation Device." Journal of Pharmaceutical Sciences 60 (10) : 1559-1564 (1971)
  • Cicerone et al., "Stratosphric Ozone Destruction by Man-Made Clorofluoromethanes." Science 185: 1165-1167 (1974)
  • Clay et al., "Assessment Of Jet Nebulisers For Lung Aerosol Therapy." The Lancet:592-594 (1983)
  • Clay et al., "Factors influencing the size distribution of aerosols from jet nebulisers." Thorax 38: 755-759 (1983)
  • Cockcroft et al., "Importance of Evaporative Water Losses During Standardized Nebulized Inhalation Provocation Tests." Chest 96(3) : 505-508 (1989)
  • Hallworth, G. W., "The formulation and evaluation of pressurised metered-dose inhalers." In Drug Delivery to the Respiratory Tract (Garderton and Jones, eds.) Ellis Horwood, Engl., pp. 87-118 (1987)
  • Jones, Kevin, "New delivery system for asthma drugs." The Practitioner 233: 265-267 (1989)
  • Kelsen et al., "Airborne Contamination of Fine-Particle Nebulizers." JAMA 237 (21) : 2311-2314 (1977)
  • Kongerud et al., "Room temperature influences output from the Wright jet nebulizer." Eur. Respir. J. 2: 681-684 (1989)
  • Newman, Stephen P., "Therapeutic aerosols." In Aerosols and the Lung:Clinical and Experimental Aspects. (Clarke and Pavia, eds.) Butterworths, Chapter 9. (1987)
  • Popa et al., "Domiciliary metaproterenol nebulization: A bacteriologic survey." J. Allergy Clin. Immunol 82 (2) : 231-236 (1988)
  • Ribeiro and Wiren, "Comparison of Bricanyl Turbuhaler and Berotec dry powder inhaler." Allergy 45: 382-385 (1990)
  • Sterk et al., "Physical Properties Of Aerosols Produced By Several Jet-And Ultrasonic Nebulizers." Bull. Eur. Physiopathol. Respir. 20: 65-72 a91984)
  • Tillery et al., "Generation and Characterization of Aerosols and Vapors for Inhalation Experiments." Environmental Health Perspectives 16: 25-40 (1976)
  • Witek and Schachter, Detection of Sulfur Dioxide in Bronchodilator Aerosols. Chest 86(4) : 592-594 (1984)
  • Wetterlin, Kjell, "Turbuhaler: A New Powder Inhaler for Administration of Drugs to the Airways." Pharmaceutical Research 5 (8) : 506-508 (1988
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