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Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use

Patent 5874418 Issued on February 23, 1999. Estimated Expiration Date: Icon_subject May 5, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3426011

3816393

Inclusion compound of lankacidin-group antibiotic and use thereof
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Inventor: Harada ,   et al.

Water soluble cyclodextrin polymers substituted by ionic groups and process for the preparation thereof
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Inclusion complex of ଲ-cyclodextrin and digoxin
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Water-soluble mixed ethers of ଲ-cyclodextrin and a process for their preparation
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Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
Patent #: 4596795
Issued on: 06/24/1986
Inventor: Pitha

Ethers of beta-cyclodextrin and a process for their preparation
Patent #: 4638058
Issued on: 01/20/1987
Inventor: Brandt ,   et al.

Pharmaceutical preparations containing cyclodextrin derivatives
Patent #: 4727064
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Inventor: Pitha

Partially methylated cyclodextrins and process for producing the same
Patent #: 4746734
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Inventors

Assignee

Application

No. 851006 filed on 05/05/1997

US Classes:

514/58, Dextrin or derivative514/778, Starch or derivative514/964, SUSTAINED OR DIFFERENTIAL RELEASE TYPE514/965, Discrete particles in supporting matrix536/103Dextrin or derivative

Examiners

Primary: Kunz, Gary L.

Attorney, Agent or Firm

International Classes

A61K 031/735
C07H 013/12
C08B 037/16

Abstract

Sulfoalkyl ether-cyclodextrin (SAE-CD) based pharmaceutical formulations are provided by the present invention. These formulations comprise SAE-CD derivatives and a therapeutic agent, a major portion of which is not complexed to the SAE-CD. The present formulations are advantageously easier to prepare than other SAE-CD based formulations in the art yet provide similar or improved effectiveness. The SAE-CD derivative can be used to modify the bioavailability and/or rate of bioabsorption of therapeutic agents.

Other References

  • Pharmaceutical Dosage Forms --Tablets, vol. 1, 2nd Edition, Herbert A. Lieberman, ed., pp. 372-376, 1990
  • Okimoto, et al., "The Interaction of Charged and Uncharged Drugs with Neutral (HP-ଲ-CD) and Anionically Charged (SEB7-ଲ-CD) ଲ-Cyclodextrins," Pharmaceutical Research, 13(2) :256-264, 1996
  • Muller, et al., "Cyclodextrin Derivatives for Solubilisation, Stabalisation, and Absorption of Drugs," Proceedings of the Fourth International Symposium on Cyclodextrins, pp. 369-382, 1988
  • Pitha, Josef, "Amorphous Water Soluble Derivatives of Cycodextrins: From Test Tube to Patient," Third International on Recent Advances in Drug Delivery Systems, pp. 1-12, 1987
  • Brewster, et al., "Improved Delivery Through Biological Membranes XXXI: Solubilization and Stabilization of an Estradiol Chemical Delivery System by Modified ଲ-Cyclodextrins," J. Pharm. Sci., 77(11):981-985, Nov. 1988
  • Muranushi, et al., "Studies on Benexate CD: Effect of Inclusion Compound Formation on the Anti-Ulcer Activity of Benexate, the Effective Ingredient in Benexate CD," Folia Pharmacol. Japan, 91(6):377-383, 1988
  • Torres-Lanbandeira, et al., "Biopharmaceutical Stability of the Glibornuride/ଲ-Cyclodextrin Inclusion Complex After One Year of Storage," S.T.P. Pharma. Sciences, 4(3) :235-239, 1994
  • Peri, et al., "Inclusion Complexes of Tolnaftate with ଲ-Cyclodextrin and Hydroxypropyl ଲ-Ctckidextrub ," Drug Development and Industrial Pharmacy, 20(8):1401-1410, 1994
  • Otero-Espinar, et al., "Oral Bioavailability of Naproxen-ଲ-Cyclodextrin Inclusion Compound," Internat. J. of Pharmaceutics, 75: 37-44, 1991
  • Lin, et al., "Solid Particulates of Drug --ଲ-Cyclodextrin Inclusion Complexes Directly Prepared by a Spray-Drying Technique," Intern. J. of Pharmaceutics, 56:249-259, 1989
  • Esclusa-Diaz, et al., "Preparation and Evaluation ofKetoconazole --ଲ-Cyclodextrin Multicomponent Complexes," Intern. J. of Pharmaceutics, 142:183-187, 199
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