Lateralization spectrophotometer

Patent 5873821 Issued on February 23, 1999. Estimated Expiration Date:

February 23, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

2790438

3461856

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Inventors

Assignee

Baylor College of Medicine

Application

No. 150084 filed on 11/15/1993

US Classes:

600/310, Infrared, visible light, or ultraviolet radiation directed on or through body or constituent released therefrom600/323, Oxygen saturation, e.g., oximeter600/334With tissue perfusion

Examiners

Primary: Nasser, Robert L.

Attorney, Agent or Firm

Fish & Richardson P.C.

Foreign Patent References

0 102 816 EP. 03/23/1984
0 282 234 EP. 09/23/1988
0 488 565 A1 EP. 06/23/1992
2 228 314 GB. 08/23/1990
WO 90/09003 WO. 08/23/1990
WO 92/13598 WO. 08/23/1992

International Class

A61B 005/00

Abstract

The present invention utilizes differential measurement of radiation that migrated into two migration paths between two source-detector pairs placed on the head in a manner that each path is localized in a portion of one hemisphere of the brain. The present invention also provides various embodiments of spectrophotometer systems for in vivo examination of tissue of a human by measuring changes in electromagnetic radiation scattered and absorbed in a migration path in the tissue. Generally, the spectrophotometer systems comprise a light source for introducing the radiation into the tissue, a detector for detecting radiation that has migrated in the tissue, a processor for processing signals of the detected radiation to create processed data, and a system for determining physiological or pathophysiological changes in the tissue of interest. The present invention also provides for determining the metabolic condition of an aerobically stressed portion of tissue such as the muscle tissue of an exercising person.

Other References

Grinvald et al., "Functional Architecture of Cortex Revealed by Optical Imaging of Intrinsic Signals", Nature vol. 324 pp. 361-364, 1986
"Watching the Brain at Work", I.E.E.E. Spectrum, vol. 20, No. 3 pp. 52-57, 1983
Millikan, "Experiments on Muscle Haemoglobin in vivo; the Instantaneous Measurement of Muscle Metabolism", Proceedings of the Royal Society of London, vol. 123, 1937, pp. 218-24