U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Formulation of 5-HT agonist and NSAID for treatment of migraine

Patent 5872145 Issued on February 16, 1999. Estimated Expiration Date: Icon_subject August 14, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Inventor: Ogletree

Indole derivatives as 5-HT1-like agonists for use in migraine
Patent #: 5607960
Issued on: 03/04/1997
Inventor: Wythes

Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines Patent #: 5618816
Issued on: 04/08/1997
Inventor: Crenshaw, et al.

Inventor

Application

No. 907826 filed on 08/14/1997

US Classes:

514/415, The bicyclo ring system consists of the five-membered hetero ring and a benzene ring (e.g., indole, etc.)514/569, Polycyclo ring system514/570, Carboxy or salt thereof only attached indirectly to the benzene ring514/629R is hydrogen or a lower saturated alkyl of less than seven carbons

Examiners

Primary: Jarvis, William R. A.

Attorney, Agent or Firm

Foreign Patent References

  • 2162522 GB. 08/13/1985

International Classes

A61K 031/405
A61K 031/19
A61K 031/16

Abstract

This invention comprises a method of treating migraine in a human comprising co-timely administering of a therapeutically effective amount of a 5-HT agonist coordinated with a therapeutically effective amount of an analgesic, particularly a long-acting NSAID in doses below those ordinarily considered as minimum effective doses as to both 5-HT agonist and long-acting NSAID. Dosage forms are also included herein.

Other References

  • Anderson, "Double-blind study of naproxen vs placebo in the treatment of acute migraine." (1989); Cephalalgia, vol. 9, 29-32
  • Baumel, "Migraine: A pharmacological review with newer options and delivery modalities," (1994), Neurology, vol. 44Supp3, S13-S17
  • Boureau, "Comparison of subcutaneous sumatriptan with usual acute treatments for migraine. French Sumatriptan Group." (1995) Eur. Neurol., vol. 35(5), 264-269
  • Bousser, Efficacy of subcutaneous sumatriptanin the acute treatment of early-morning migraine: a placebo-controlled trial. Early-Morning Sumatriptan Study Group (1993) J Intern Med, vol. 234(2), 211-216
  • Cady, "Treatment of Acute Migraine With Subcutaneous Sumatriptan." (1991) JAMA, vol. 265,No. 21, 2831-2835
  • Cady, "Efficacy of subcutaneous sumatriptan in repreated episodes of migraine" (1993) Neurology, vol. 43, 1363-1368
  • Centonze, "Evaluation of the efficacy of oral sumatriptan in the management of migraine attacks. Clinical Results" (1995) La Clinica Teraputica, vol. 146(11), 721-728 (Article in the Italian language, Citation to English language abstract only at 727)
  • Dechant, "Sumatriptan A review of its Pharmacodynamic Properties, and Therapeutic Efficacy in the Acute Treatment of Migraine and Cluster Headache" (1992) Drugs, vol. 43(5) 776-798
  • Klapper, "Toward a Standard Drug Formulary for the Treatment of Headache" (1995) Headache, Apr., 1995, 225-227
  • Oral Sumatriptan Group, "Sumatriptan--An Oral Dose-defining Study" (1991) Eur. Neurol., vol. 31, 300-305
  • Thomson, "A Study to Compare Oral Sumatriptan with Oral Aspirin plus Oral Metoclopramide in the Acute Treatment of Migraine" (1992) Eur. Neurol., vol. 32, 177-184
  • Todd, "Naproxen A reappraisal of its Pharmacology, and Therapeutic Use in Rheumatic Diseases and pain States" (1990) Drugs, vol. 40(1), 91-137
  • Tokola, "Effects of migraine attack and metoclopramide on the absorption of tolfenamic acid" (1984) Br. J Clin. Pharmac, vol. 17, 67-75
  • Tokola, "Tolfenamic acid, metoclopramide, caffeine and their combinations in the treatment of migraine attacks" (1984) Cephalalgia, vol. 4, 253-26
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