Synthesis of 9-deoxo-9a-aza-11,12-deoxy-9a-methyl-9a-homoerythromycin A 11,12 Hydrogenorthoborate dihydrate and a process for the preparation of azitromicin dihydrate

Patent 5869629 Issued on February 9, 1999. Estimated Expiration Date:

July 11, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Process for the treatment of aromatic polyamide fibers, which are suitable for use in construction materials and rubbers, as well as so treated fibers and shaped articles reinforced with these fibers
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11-Aza-10-deoxo-10-dihydroerythromycin A and derivatives thereof as well as a process for their preparation
Patent #: 4328334
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Inventors

Assignee

Astur-Pharma, S.A.

Application

No. 890771 filed on 07/11/1997

US Classes:

536/7.2, Erythromycin or derivative (e.g., oleandomycin, etc.)536/7.1, Oxygen containing hetero ring having 12-19 members (e.g., methymycin, carbomycin, spiramycin, etc.)536/7.3, Boron, phosphorus or sulfur containing536/7.4, Additional nitrogen containing536/7.5Purification or recovery

Examiners

Primary: Wilson, James O.

Attorney, Agent or Firm

Michaelson & Wallace, Michaelson; Peter L., Fink; Edward M.

International Class

C07H 017/08

Foreign Application Priority Data

1996-07-11 ES

Abstract

The preparation of azitromycin dihydrate from 9-deoxo-9a-aza-11,12-deoxy-9a-methyl-9a-homoerythromycin A 11,12-hydrogenorthoborate, obtained by a step by step process starting from 9-deoxo-6-deoxy-6,9-epoxy-9,9a-dihydro-9a-azahomoerythromycin A is a process which takes place under mild conditions and with good yields.