U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents

Patent 5869079 Issued on February 9, 1999. Estimated Expiration Date: Icon_subject February 9, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Ocular preparation housing steroid in two different therapeutic forms
Patent #: 4478818
Issued on: 10/23/1984
Inventor: Shell ,   et al.

Biodegradable ocular implants
Patent #: 4997652
Issued on: 03/05/1991
Inventor: Wong

Process for polymerizing poly(lactic acid)
Patent #: 5075115
Issued on: 12/24/1991
Inventor: Brine

Biodegradable ocular implants
Patent #: 5164188
Issued on: 11/17/1992
Inventor: Wong

Composition for effecting bone repair
Patent #: 5356629
Issued on: 10/18/1994
Inventor: Sander, et al.

Formulations for delivery of osteogenic proteins Patent #: 5385887
Issued on: 01/31/1995
Inventor: Yim, et al.

Inventors

Assignee

Application

No. 459134 filed on 06/02/1995

US Classes:

424/426, Errodable, resorbable, or dissolving424/423, Surgical implant or material514/953SHAPED FORMS ADAPTED FOR NONINGESTIBLE USE OTHER THAN SUPPOSITORY TYPE (E.G., FILMS, INSERTS, ETC.)

Examiners

Primary: Webman, Edward J.

Attorney, Agent or Firm

International Classes

A61K 047/34
A61K 047/36
A61K 009/10

Abstract

Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent and modulator provide controlled, sustained drug release for an extended period of time.

Other References

  • R. Baker, "Controlled Release of Biologically Active Agents," A Wiley-Interscience Publication, p. 73 (1987)
  • Heller, Biodegradable Polymers in Controlled Drug Delivery (1987) CRC Critical Reviews in Therapeutic Drug Carrier Systems, vol. 1, Issue 1:39-90
  • Miller et al., Degradation Rates of Oral Resorbable Implants (Polylactates and Polyglycolates): Rate Modification with Changes in PLA/PGA Copolymer Ratios (1977) J. Biomed. Mater. Res., vol. 11:711-719
  • Di Colo, Controlled Drug Release From Implantable Matrices Based On Hydrophobic Polymers (1992) Biomaterials, vol. 13, No. 12:850-856
  • Jackanicz et al., Polyactic Acid As A Biogradable Carrier For Contraceptive Steroids (1973) Contraception, vol. 8, No. 3:227-23
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