Bradykinin antagonists

Patent 5863899 Issued on January 26, 1999. Estimated Expiration Date:

January 26, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Method of regulating hormone function or release
Patent #: 4618598
Issued on: 10/21/1986
Inventor: Conn

Toxin conjugates Patent #: 4894443
Issued on: 01/16/1990
Inventor: Greenfield, et al.

Inventors

Assignee

Cortech, Inc.

Application

No. 296185 filed on 08/29/1994

US Classes:

514/15, 9 to 11 peptide repeating units in known peptide chain530/314, Bradykinin; kallidin; related peptides530/328, 8 to 10 amino acid residues in defined sequence530/395, Glycoprotein, e.g., mucins proteoglycans, etc.530/402Chemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc.

Examiners

Primary: Achutamurthy, Ponnathapu
Assistant: Wessendorf, T. D.

Attorney, Agent or Firm

Burke; John

International Classes

A61K 038/08
C07K 007/18

Abstract

A bradykinin antagonist of the formula:(BKAn) (X) (Y)where BKAn is a bradykinin antagonist peptide; Y is a Pharmacophore; and X is a bridging link chemically joining the BKAn and Y components.

Other References

Kodama et al, European Journal of Pharmacology, vol. 151, pp. 317-320 (1988)
Vavmek et al, J. Peroc. 8^th Am. Pept. Sump., pp. 381-384, (1983)
Cheronis et al, J. of Medicinal Chemistry, vol. 35, pp. 1563-1572, (1992)
Stewart et al, Adv. Exp. Med. Biol., Kinias-3, Pt. A, pp. 585-589, (1983)
Carr, "The Effect of Anti-Inflammatory Durgs on Increased Vascular Permeability Induced by Chemical Mediators," The Journal of Pathology, vol. 108 (1), (1972) pp. 1-14
Calixto et al, "Nonpeptide Bradykinin Antagonists", (1991), pp. 97-129
Cheronis et al, "Bradykinin Antagonists: Synthesis and in vitro Activity of Bissuccinimidoalkane Peptide Dimers" Recent Progress on Kinins, (1992) pp. 551-55