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Biosensor and method for hematocrit determination Patent #: 5385846
ApplicationNo. 816188 filed on 03/12/1997
US Classes:427/96.9, Front and back of substrate coated (excluding processes where all coating is by immersion)29/852, By forming conductive walled aperture in base204/403.13, And microelectrode (i.e., at least one electrode dimension is less than 500 microns)204/412, Three or more electrodes204/415, Selectively permeable membrane204/416, Ion-sensitive electrode204/418, Organic membrane204/419, Inorganic membrane427/58, ELECTRICAL PRODUCT PRODUCED427/97.2, Coating hole wall427/102, Nonuniform coating427/103, Applying superposed diverse coatings or coating a coated base427/124Vapor deposition or utilizing vacuum
ExaminersPrimary: Tung, T.
Attorney, Agent or Firm
International ClassG01N 027/403
AbstractThe present invention is an electronic wiring substrate for sensors formed over a subminiature through hole. Because of the small diameter of the through hole, the material that fills the through hole and the through hole itself have an essentially negligible effect on the sensor. Only a small amount of conductive material which fills each through hole is in contact with each associated electrode. Therefore, the purity of the electrode is not significantly altered by the conductive material coupled to the electrode. A relatively large number of sensors can be formed on the surface of the substrate within a relatively small fluid flowcell. Thus, more information can be attained using less blood. The substrate is essentially impervious to aqueous electrolytes and blood over long periods of storage in potentially corrosive environments. Since the substrate does not break down or become unstable when exposed over time to such reactive environments, the isolation that is provided by the substrate remains very high between each sensor and each other sensor, between each sensor and each conduction path, and between each conduction path and each other conduction path. The superior isolation provided by the substrate provides for a high level of accuracy in the sensor of the present invention. This physical isolation of the sample from the conduction paths between the sensor electrodes and external devices ensures very high electrical isolation between each of the sensors is maintained over an extended period time during which corrosive fluids (such as electrolytes and/or blood) are present in the flowcell.