Guanylhydrazones and their use to treat inflammatory conditions
Patent 5854289 Issued on December 29, 1998. Estimated Expiration Date: 
April 15, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 15, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3560557 3799988 InventorsAssigneeApplicationNo. 632305 filed on 04/15/1996US Classes:514/615, R contains benzene ring514/597, Benzene ring is part of a substituent which contains nitrogen514/614, N-N containing (e.g., aminimine, hydrazine, etc.)514/616, Plural carboxamide groups or plural C=O groups bonded directly to the same nitrogen514/632, Amidino hydrazines or hydrazones (i.e., N-N=C-N or N=C-N-N)514/634, Guanidines (i.e., N=C(-N)-N)514/636, Polyamidines514/825, ARTHRITIS514/903MULTIPLE SCLEROSISExaminersPrimary: Kumar, ShailendraAttorney, Agent or FirmInternational ClassesA61K 031/16A61K 031/155 AbstractThis invention concerns new methods and compositions that are useful in preventing and ameliorating cachexia, the clinical syndrome of poor nutritional status and bodily wasting associated with cancer and other chronic diseases. More particularly, the invention relates to aromatic guanylhydrazone (more properly termed amidinohydrazone) compositions and their use to inhibit the uptake of arginine by macrophages and/or its conversion to urea. These compositions and methods are also useful in preventing the generation of nitric oxide (NO) by cells, and so to prevent NO-mediated inflammation and other responses in persons in need of same. In another embodiment, the compounds can be used to inhibit arginine uptake in arginine-dependent tumors and infections, and autoimmune or other diseases in which activated macrophages are involved, such as septic shock, heumatoid arthritis and multiple sclerosis.Other References
Field of SearchBenzene ring bonded directly to urea nitrogenBenzene ring is part of a substituent which contains nitrogen Amidino hydrazines or hydrazones (i.e., N-N=C-N or N=C-N-N) Guanidines (i.e., N=C(-N)-N) Polyamidines Nitrogen attached indirectly to the six-membered hetero ring by nonionic bonding ARTHRITIS MULTIPLE SCLEROSIS N-N containing (e.g., aminimine, hydrazine, etc.) R contains benzene ring Plural carboxamide groups or plural C=O groups bonded directly to the same nitrogen | |
