Therapeutic delivery using compounds self-assembled into high axial ratio microstructures

Patent 5851536 Issued on December 22, 1998. Estimated Expiration Date:

November 21, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Assignee

University of Washington

Application

No. 752848 filed on 11/21/1996

US Classes:

424/400, PREPARATIONS CHARACTERIZED BY SPECIAL PHYSICAL FORM424/450Liposomes

Examiners

Primary: Kishore, Gollamudi S.

Attorney, Agent or Firm

Klarquist Sparkman Campbell Leigh & Whinston, LLP

International Classes

A61K 009/00
A61K 009/127

Abstract

Therapeutic agents comprising plural therapeutic compounds self assembled into high axial ratio microstructures are described. The threapeutic compounds satisfy the formula HARFM-Th, wherein HARFM is a high axial ratio forming material and Th is a therapeutic associated with the HARFM. The therapeutic agent also can satisfy the formula HARFM-S-Th, wherein S is a spacer. Release of the therapeutic by the agent generally follows either 0-order kinetics or psuedofirst order kinetics. A method for delivering drugs to animals or persons also is described. The method comprises administering an effective amount of a therapeutic self-assembled into an HAR microstructure to the animal or person.