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US Patent 5851536 - Therapeutic delivery using compounds self-assembled into high axial ratio microstructures

US Patent Issued on December 22, 1998
Estimated Patent Expiration Date: Icon_subject November 21, 2016Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

Therapeutic agents comprising plural therapeutic compounds self assembled into high axial ratio microstructures are described. The threapeutic compounds satisfy the formula HARFM-Th, wherein HARFM is a high axial ratio forming material and Th is a therapeutic associated with the HARFM. The therapeutic agent also can satisfy the formula HARFM-S-Th, wherein S is a spacer. Release of the therapeutic by the agent generally follows either 0-order kinetics or psuedofirst order kinetics. A method for delivering drugs to animals or persons also is described. The method comprises administering an effective amount of a therapeutic self-assembled into an HAR microstructure to the animal or person.

Other References

  • Tovchilin in BBRC. 85, #3, pp. 983-990, Dec. 197

Inventors

Assignee

Application

No. 752848 filed on 11/21/1996

US Classes:

424/400, PREPARATIONS CHARACTERIZED BY SPECIAL PHYSICAL FORM424/450Liposomes

Field of Search

424/400, PREPARATIONS CHARACTERIZED BY SPECIAL PHYSICAL FORM424/450, Liposomes424/443, Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments428/357, COATED OR STRUCTUALLY DEFINED FLAKE, PARTICLE, CELL, STRAND, STRAND PORTION, ROD, FILAMENT, MACROSCOPIC FIBER OR MASS THEREOF428/221WEB OR SHEET CONTAINING STRUCTURALLY DEFINED ELEMENT OR COMPONENT

Examiners

Primary: Kishore, Gollamudi S.

Attorney, Agent or Firm

US Patent References

4871488, Reconstituting viral glycoproteins into large phospholipid vesicles
Issued on: 10/03/1989
Inventor: Mannino ,   et al.
4990291, Method of making lipid tubules by a cooling process
Issued on: 02/05/1991
Inventor: Schoen, et al.
5643574Protein- or peptide-cochleate vaccines and methods of immunizing using the same
Issued on: 07/01/1997
Inventor: Gould-Fogerite, et al.

International Classes

A61K 009/00
A61K 009/127

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