Composition containing peptides and nucleic acids and methods of making same
Patent 5849196 Issued on December 15, 1998. Estimated Expiration Date: 
October 7, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 7, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesPeptide nucleic acids Patent #: 5539082 InventorAssigneeApplicationNo. 726650 filed on 10/07/1996US Classes:210/651, Removing specified material424/520, EXTRACT, BODY FLUID, OR CELLULAR MATERIAL OF UNDETERMINED CONSTITUTION DERIVED FROM ANIMAL IS ACTIVE INGREDIENT424/529, Blood424/535, Milk or colostrum (e.g., butter, whey, etc.)514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/7, Phosphorus containing514/44Polynucleotide (e.g., RNA, DNA, etc.)ExaminersPrimary: Elliott, George C.Assistant: Larson, Thomas G. Attorney, Agent or FirmInternational ClassesB01D 061/24A61K 035/14 A61K 035/20 A61K 035/72 AbstractAn improved composition containing peptides and nucleic acids has active components, i.e., which heighten the phagocytic activity f neutrophils, consisting of molecules with a molecular weight of at least 8 kDa, and preferably at least 15 kDa. The active components comprise peptides without aromatic portions and will absorb light at an absorption band of Ɗλ=200-235 mn, λmax =205 nm, in the UV spectrum. The composition is nontoxic and is formulated using casein, blood albumin, beef peptone, nucleic acid (RNA) and a base such as sodium hydroxide. The composition stimulates phagocytic activity of neutrophils if used at sufficient concentrations. A separate composition is obtained using the same components of manufacture, but filtering or centrifuging the composition to a molecular weight of <8-15 kDa which inhibits phagocytic activity of neutrophils for application in treating auto immune diseases.Other References
Field of SearchPolynucleotide (e.g., nucleic acid, oligonucleotide, etc.)Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI Phosphorus containing Polynucleotide (e.g., RNA, DNA, etc.) PEPTIDES OF 3 TO 100 AMINO ACID RESIDUES PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES Casein or caseinate Serum albumin, e.g., BSA, HSA, etc. DNA or RNA fragments or modified forms thereof (e.g., genes, etc.) Removing specified material EXTRACT, BODY FLUID, OR CELLULAR MATERIAL OF UNDETERMINED CONSTITUTION DERIVED FROM ANIMAL IS ACTIVE INGREDIENT Blood Milk or colostrum (e.g., butter, whey, etc.) | |
