Polyphoshoinositide binding peptides for intracellular drug delivery
Patent 5846743 Issued on December 8, 1998. Estimated Expiration Date: 
November 22, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 22, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesOligopeptide prodrugs Detection of necrotic malignant tissue and associated therapy Method for enhanced transmembrane transport of exogenous molecules Basic protein phospholiphase A2 Method of determining extinction coefficient of fluorescent dye and protein concentration of dye-protein conjugate Pro-cytotoxic drug conjugates for anticancer therapy Patent #: 5502037 InventorsAssigneeApplicationNo. 755496 filed on 11/22/1996US Classes:435/7.8, Involving nonmembrane bound receptor binding or protein binding other than antigen-antibody binding435/4, MEASURING OR TESTING PROCESS INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITION OR TEST STRIP THEREFORE; PROCESSES OF FORMING SUCH COMPOSITION OR TEST STRIP435/6, Involving nucleic acid435/7.21, Animal cell435/7.23, Tumor cell or cancer cell435/244, Chemical stimulation of growth or activity by addition of chemical compound which is not an essential growth factor; stimulation of growth by removal of a chemical compound514/15, 9 to 11 peptide repeating units in known peptide chain514/16, 7 or 8 peptide repeating units in known peptide chain530/3288 to 10 amino acid residues in defined sequenceExaminersPrimary: Prouty, Rebecca E.Assistant: Longton, Enrique D. Attorney, Agent or FirmForeign Patent References
International ClassG01N 033/53AbstractMethods and compositions for facilitating the transport of a membrane-impermeable extracellular agent having an intracellular activity across the membrane of a cell are provided. The methods involve covalently coupling an amino terminal blocking group to a transport-mediating peptide to form a carrier molecule. The carrier molecule is covalently coupled to the extracellular agent to form a membrane-permeable prodrug. The transport-mediating peptides are highly basic and bind to polyphosphoinositides.Other References
Field of Search9 to 11 peptide repeating units in known peptide chain7 or 8 peptide repeating units in known peptide chain 8 to 10 amino acid residues in defined sequence Chemical stimulation of growth or activity by addition of chemical compound which is not an essential growth factor; stimulation of growth by removal of a chemical compound MEASURING OR TESTING PROCESS INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITION OR TEST STRIP THEREFORE; PROCESSES OF FORMING SUCH COMPOSITION OR TEST STRIP Involving nucleic acid Animal cell Tumor cell or cancer cell Involving nonmembrane bound receptor binding or protein binding other than antigen-antibody binding |
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