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US Patent 5844002 - Method for inducing bronchodilation using optically pure R(-) albuterol

US Patent Issued on December 1, 1998
Estimated Patent Expiration Date: Icon_subject April 21, 2018Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with albuterol.

Other References

  • Tan et al. "Stereoselective Disposition of Salbutamol Enantiomers . . . " Clin. Chem. 33, 1026 (1987)
  • Brittain et al. "Some observations on the ଲ-adrenoceptor agonist . . . " Br. J. Pharmac. 48, 144-147 (1973)
  • Hartley et al. "Absolute Configuration of the Optical Isomers of Salbutamol" J. Med. Chem. 12, 995 (1971)
  • Hawkins et al. "Relative Potency of (-)-and (&#b1;)-Salbutamol on Guinea Pig . . . " J. Med. Chem. 16, 856-857 (1973)
  • Buckner et al. "Studies on the Effects of Enantiomers of Soterenol, Trimetoquinol . . . " J. Pharm. Exp. Ther. 189, 616-625 (1974)
  • Passowicz-Muszynska E. "Effect on beta adrenergic receptors of tachyphylaxis . . . " Index Medicus 91:164287
  • Pauwels "Effect of corticosteroids on the action of sympathomimetics" Index Medicus 86:051970
  • Chapman et al. "An anomalous effect of salbutamol in sensitised guinea pigs" Brit. J. Pharmacol 99, 66P (1990)
  • Morley et al. "Effects of (+) and racemic salbutamol on airway responses in the guinea pig" Brit. J. Pharmacol. 104, 295P (1991)
  • Chapman et al. "Racemic mixtures at root of worsening symptoms? Active enantiomers . . ." TIPS 13, 231-232 (1992)
  • Muittari et al. "Comparison of acute bronchodilator effects of oral salbutamol, . . . " Chem. Abstr. 89: 123259m (1978

Inventors

Assignee

Application

No. 063551 filed on 04/21/1998

US Classes:

514/649, Amino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chain514/826ASTHMA

Field of Search

514/649, Amino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chain514/826ASTHMA

Examiners

Primary: Henley, III, Raymond

Attorney, Agent or Firm

US Patent References

5362755, Method for treating asthma using optically pure (R)-albuterol
Issued on: 11/08/1994
Inventor: Barberich, et al. 5547994, 5760090Method for treating asthma using optically pure R(-) albuterol
Issued on: 06/02/1998
Inventor: Barberich, et al.

Foreign Patent References

  • 2128258 DE. 03/20/1983
  • 1298494 GB. 03/20/1971
  • 2 255 503 GB. 03/20/1992

International Class

A61K 031/135

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