2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative

Patent 5840891 Issued on November 24, 1998. Estimated Expiration Date:

March 4, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
Patent #: 4355032
Issued on: 10/19/1982
Inventor: Verheyden , et al.

Antiviral compounds Patent #: 5043339
Issued on: 08/27/1991
Inventor: Beauchamp

Inventors

Application

No. 812990 filed on 03/04/1997

US Classes:

544/276Nitrogen attached directly or indirectly to the purine ring system by nonionic bonding

Examiners

Primary: Berch, Mark L.

Attorney, Agent or Firm

Heller Ehrman White & McAuliffe

Foreign Patent References

0 158 847 EP. 10/13/1985
0 187 297 EP. 07/13/1986
0 249 248 EP. 12/13/1987
0 308 065 EP. 03/13/1989
0 375 329 EP. 06/13/1990
1 523 865 GB. 06/13/1978
2 104 070 GB. 03/13/1983
2 122 618 GB. 01/13/1984
8829571 GB. 06/13/1990
WO 94/29311 WO. 12/13/1994

International Classes

C07D 473/18
A61K 031/52

Abstract

The L-monovaline ester derived from 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.

Other References

E. Jensen et al., "Systhesis, enzymatic hydrolysis and physico-chemical properties . . . ", Acta Phar. Nord., 3(4), 243-247 (1991)
J.C. Martin et al., "Synthesis and Antiviral Activity of Various Esters . . . ", J. Pharm. Sci., 76(2), 180-184 (1987)
P.C. Maudgal et al., "Topical Treatment of Experimental Herpes Simplex Keratouveitis . . . ", Arch. Ophthalmol., 102, 140-142 (1984)
L. Colla et al., "Synthesis and Antiviral Activity of Water-soluble Esters of Acyclovir . . . ", J. Med. Chem., 26, 602-604 (1983)
L.M. Beauchamp et al., "Amino acid ester prodrugs of acyclovir", Antiviral Chemistry & Chemotherapy, 3(3), 157-164 (1992