Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
Patent 5840890 Issued on November 24, 1998. Estimated Expiration Date: 
January 9, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 9, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent Antiviral compounds Patent #: 5043339 InventorsApplicationNo. 775424 filed on 01/09/1997US Classes:544/276, Nitrogen attached directly or indirectly to the purine ring system by nonionic bonding435/119Containing at least two hetero rings bridged or fused among themselves or bridged or fused with a common carbocyclic ring system, (e.g., rifamycin, etc.)ExaminersPrimary: Berch, Mark L.Attorney, Agent or FirmForeign Patent References
International ClassesC07D 473/18C07B 051/00 AbstractProcess and novel intermediates for preparing the mono-L-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol ganciclovir) and its pharmaceutically acceptable salts. The present process and monoester intermediates provide for mono-esterification by an L-valine derivative, resulting in a monocarboxylate-monovalinate which is then selectively hydrolyzed under basic or enzymatic conditions to give the monovaline ester of ganciclovir in high yield and purity. These products are of value as antiviral agents with improved absorption.Other References
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