U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Process to prepare oxazolidinones

Patent 5837870 Issued on November 17, 1998. Estimated Expiration Date: Icon_subject March 28, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3547951

5-Benzyl-2-oxazolidone derivatives and a process for producing the same
Patent #: 4062862
Issued on: 12/13/1977
Inventor: Fujimoto ,   et al.

3-Aryl 2-oxazolidinones, their process of preparation and their therapeutical application
Patent #: 4150029
Issued on: 04/17/1979
Inventor: Dostert ,   et al.

5-Phenethyl-2-oxazolidone derivatives and a process for producing the same
Patent #: 4236012
Issued on: 11/25/1980
Inventor: Fujimoto ,   et al.

Novel 5-hydroxymethyl oxazolidinones, the method of preparing them and their application in therapeutics
Patent #: 4250318
Issued on: 02/10/1981
Inventor: Dostert ,   et al.

3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
Patent #: 4340606
Issued on: 07/20/1982
Inventor: Fugitt ,   et al.

P-Oxooxazolidinylbenzene compounds as antibacterial agents
Patent #: 4461773
Issued on: 07/24/1984
Inventor: Gregory

Aminomethyl-5 oxazolidinic derivatives and therapeutic use thereof
Patent #: 4476136
Issued on: 10/09/1984
Inventor: Dostert ,   et al.

Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
Patent #: 4948801
Issued on: 08/14/1990
Inventor: Carlson, et al.

5'Indolinyl-5ଲ-amidomethyloxazolidin-2-ones
Patent #: 5164510
Issued on: 11/17/1992
Inventor: Brickner

More ...

Inventors

Assignee

Application

No. 828923 filed on 03/28/1997

US Classes:

544/137, The five-membered hetero ring has at least oxygen and nitrogen as ring hetero atoms544/369, 1,3-oxazole ring or 1,3-thiazole ring (including hydrogenated)548/217, Polycyclo ring system having the oxazole ring as one of the cyclos548/221, Chalcogen bonded directly at the 2-position of the oxazole ring548/229, Chalcogen bonded directly at 2-position of the oxazole ring548/257Polycyclo ring system having the triazole ring as one of the cyclos

Examiners

Primary: Richter, Johann
Assistant: Sackey, Ebenezer

Attorney, Agent or Firm

Foreign Patent References

  • 681830 CA 03/12/1964
  • WO93/09103 WO 05/12/1993
  • WO93/23384 WO 11/12/1993
  • WO95/07271 WO 03/12/1995
  • WO96/13502 WO 05/12/1996
  • WO96/15130 WO 05/12/1996

International Classes

C07D 413/04
C07D 249/16

Abstract

The present invention includes processes for producing 5-hydroxymethyl substituted oxazolidinone alcohols (III) from carbamates (IIA) or a trifluoroacetamide (IIB) using a dihydroxy compound (I) or glycidol (IV) starting material and for the transformation of the hydroxymethyl substituted oxazolidinone alcohols (III) to the corresponding amino compounds, 5-aminomethyl substituted oxazolidinone amines (VII) which are acylated to form commercially useful antibacterial 5-acylamidomethyl substituted oxazolidinone (VIII).

Other References

  • J. Med. Chem., 32, p. 1673 (1989)
  • Tetrahedron, 45, p. 1323 (1989)
  • Abstracts of Papers, 206th National Meeting of the American Chemical Society, Chicago IL, Aug., 1993. American Chemical Society: Washington, DC 1993; ORGN 089
  • J. Med. Chem., 39, 673 (1996)
  • J. Med. Chem., 39, 680 (1996)
  • Abstracts of Papers, 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA Sep., 1995; American Society for Microbiology; Washington, DC, 1995: Abstract No. F208, F207, F206, F227
  • J. Am. Chem. Soc., 64, p. 1291 (1942)
  • Chem. Lett., p. 1057 (1978
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
 
Sign InRegister
Username  
Password   
forgot password?