Hydrazinedicarboximidamide compounds and pharmaceutical composition comprising same
Patent 5837737 Issued on November 17, 1998. Estimated Expiration Date: November 17, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/632, Amidino hydrazines or hydrazones (i.e., N-N=C-N or N=C-N-N)564/227, Guanyl hydrazines or hydrozones (i.e., HNH-N=C(-HNH)-HNH or HN=C(-HNH)-NH HNH, wherein substitution may be made for hydrogen only)564/228Benzene ring containing
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.
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November 17, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
