U.S. patents available from 1976 to present.
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Small molecule mimetics of erythropoietin

Patent 5835382 Issued on November 10, 1998. Estimated Expiration Date: Icon_subject April 26, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

System and method for determining three-dimensional structures of proteins
Patent #: 5265030
Issued on: 11/23/1993
Inventor: Skolnick, et al.

Method of design of compounds that mimic conformational features of selected peptides
Patent #: 5331573
Issued on: 07/19/1994
Inventor: Balaji, et al.

Computer graphics system for selectively modelling molecules and investigating the chemical and physical properties thereof
Patent #: 5555366
Issued on: 09/10/1996
Inventor: Teig, et al.

Method and system for protein modeling Patent #: 5557535
Issued on: 09/17/1996
Inventor: Srinivasan, et al.

Inventors

Application

No. 641071 filed on 04/26/1996

US Classes:

702/27Molecular structure or composition determination

Examiners

Primary: Trammell, James P.
Assistant: Kemper, M.

Attorney, Agent or Firm

International Classes

G06F 019/00
G06F 159/00

Abstract

The invention features computer-assisted methods for identifying molecules which will bind to the EPO receptor and act as an erythropoietin (EPO) mimetic. Preferred EPO mimetics identified using the method of the invention act as agonists of the EPO receptor in one or more in vitro or in vivo biological assays of EPO activity.

Other References

  • Livnah et al., "Functional Mimicry of a Protein Hormone by a Peptide Agonist", Science, 26 Jul. 1996, vol. 273, No. 274, pp. 464-471
  • McCarthy, "Small Peptide Designed that can Mimic Erythropoietin", Lancet, Aug. 1996, vol. 348, No. 24, p. 395
  • Wrighton et al., "Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin" Science 273:458-463, Jul. 199
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