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Use of lactoferrin for therapy of acute of chronic infectious diseases by the intracellular gram-positive pathogens streptococcus pyogenes and staphylococcus aureus

Patent 5834424 Issued on November 10, 1998. Estimated Expiration Date: Icon_subject September 5, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Formulated medicines for enhancing the efficacy of beta-lactam antibiotics in prophylaxis and treatment against infectious disease due to pathogenic bacteria
Patent #: 5198419
Issued on: 03/30/1993
Inventor: Ando, et al.

Bioactive agents and compositions for materials comprising the bioactive agent and a method for treating materials therewith
Patent #: 5296464
Issued on: 03/22/1994
Inventor: Tomita, et al.

Input circuit and method for holding data in mixed power supply mode Patent #: 5656951
Issued on: 08/12/1997
Inventor: Hu, et al.

Inventors

Assignee

Application

No. 924093 filed on 09/05/1997

US Classes:

514/8, Glycoprotein (carbohydrate containing)424/439, Food or edible as carrier for pharmaceutical424/442, Animal food424/532, Platelet424/657, Boron426/332, Animal flesh426/334, Lacteal derived containing426/335, Biocidal or disinfecting chemical agent426/442, Treatment of food material by addition of material other than water, air, carbon dioxide, nitrogen or inert gases, or mixtures thereof514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/6, Heavy metal containing (e.g., hemoglobin, etc.)514/12, 25 or more peptide repeating units in known peptide chain structure514/21, Produced by or extracted from animal tissue514/192, 1-thia-4-aza-bicyclo (3.2.0) heptane ring containing (including dehydrogenated) (e.g., penicillins, etc.)514/200, 1-thia-5-aza-bicyclo (4.2.0) octane ring containing (including dehydrogenated) (e.g., cephalosporins, etc.)530/324, 25 or more amino acid residues in defined sequence530/400, Metal containing, e.g., chromoproteins, ferritin, ferredoxins, etc.530/832Milk; colostrum

Examiners

Primary: Tsang, Cecilia J.
Assistant: Harle, Jennifer

Attorney, Agent or Firm

Foreign Patent References

  • 438750 EP. 12/13/1990
  • 431933 EP. 12/13/1990
  • 629347 EP. 11/13/1992
  • 568200 EP. 04/13/1993
  • 9413318 WO. 12/13/1993

International Classes

A61K 037/02
A61K 031/43
A61K 031/545
C07K 013/00

Foreign Application Priority Data

1995-07-12 IT

Abstract

Compositions of lactoferrin, ovotransferrin or serotransferrin in apo or iron-saturated form are provided which have bacterial anti-invasive properties against Streptococcus pyogenes and Staphylococcus aureus. Methods of treatment of epithelial calls and mucosal membranes are described.

Other References

  • Bacterial Activity of Union Lactoferrin:Sensitivity of a Variety of Microorganisms Infect Immun 28:893-898 (1980)
  • Antiviral Effects of Plasma and Milk Proteins . . . JID vol. 172, pp. 380-387 (Aug. 1995)
  • Lactoferrin INhibits Herpes Simples Virus . . . (Marchetti, Magda) (1996)
  • Antiviral Effects of Milks Proteins . . . Aids Research and Human Retrovirus (Swart, P.L.) (1996
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