Comparative fluorescence hybridization to nucleic acid arrays
Patent 5830645 Issued on November 3, 1998. Estimated Expiration Date: 
November 3, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 3, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod for detecting pathological conditions Method of preparing and applying single stranded DNA probes to double stranded target DNAs in situ Beads fused to a test device support Methods of making fluorescent microspheres Methods for chromosome-specific staining Patent #: 5447841 InventorsAssigneeApplicationNo. 353018 filed on 12/09/1994US Classes:435/6, Involving nucleic acid382/128, Biomedical applications382/129, DNA or RNA pattern reading435/91.2, Acellular exponential or geometric amplification (e.g., PCR, etc.)536/24.3, Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA536/24.33, Primers536/26.6Labelled (e.g., tagged with radioactive tracer, fluorescent marker, intercalator, etc.)ExaminersPrimary: Jones, W. GaryAssistant: Rees, Dianne Attorney, Agent or FirmForeign Patent References
International ClassesC12W 001/68C12P 019/34 C07H 021/04 AbstractThe present invention provides methods of determining relative copy number of target nucleic acids and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acids immobilized on a solid surface, to which a sample comprising two sets of differentially labeled nucleic acids are hybridized. The hybridization of the labeled nucleic acids to the solid surface is then detected using standard techniques.Other References
Field of SearchInvolving nucleic acidAcellular exponential or geometric amplification (e.g., PCR, etc.) Biomedical applications DNA or RNA pattern reading Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA Primers Labelled (e.g., tagged with radioactive tracer, fluorescent marker, intercalator, etc.) |
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