U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Disposable package for use in aerosolized delivery of drugs

Patent 5823178 Issued on October 20, 1998. Estimated Expiration Date: Icon_subject August 2, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3187748

3565070

3658059

3812854

3814297

3826413

3861386

Respiratory biofeedback and performance evaluation system
Patent #: 3991304
Issued on: 11/09/1976
Inventor: Hillsman

4090642

Medical inhalation device for the treatment of diseases of the respiratory tract
Patent #: 4119096
Issued on: 10/10/1978
Inventor: Drews

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Inventors

Assignee

Application

No. 693593 filed on 08/02/1996

US Classes:

128/200.14, LIQUID MEDICAMENT ATOMIZER OR SPRAYER128/200.22, Gas flow induced by expansion chamber device (e.g., piston/cylinder ram, squeeze bulb, etc.)128/203.12, Means for mixing treating agent with respiratory gas128/204.23Means for sensing condition of user's body

Examiners

Primary: Lewis, Aaron J.

Attorney, Agent or Firm

Foreign Patent References

  • 0 432 992 EP. 06/13/1991
  • 0 469 814 EP. 02/13/1992
  • 28 35 135 DE. 02/13/1980
  • 41 33 274 DE. 02/13/1993
  • 0530625 DE. 03/13/1993
  • 2055046 GB 02/13/1981
  • 2 255 918 GB. 11/13/1992
  • 2255918 GB. 11/13/1992
  • 0546607 GB. 06/13/1993
  • WO 92/07599 WO. 05/13/1992
  • WO 92/11050 WO. 07/13/1992
  • WO 93/03785 WO. 03/13/1993
  • WO 93/09832 WO. 05/13/1993

International Class

A61M 011/00

Abstract

A disposable package, tape, and cassette are provided which makes it possible to hold and disperse therefrom liquid, flowable formulations including aqueous formulations (solutions or dispersions with particles less than 0.25 microns in diameter) of a pharmaceutically active drug. In one embodiment formulation is packaged in individual dosage unit containers which containers are preferably interconnected. The package is designed to be integrated into a cassette which can be loaded into a dispersing device capable of individually opening dosage unit containers and aerosolizing the contents through a porous membrane, into a mouth piece on the cassette, for delivery to a patient. In addition to and alongside of each porous membrane, the package may include one or more openings through which air is forced in order to aid in avoiding the accumulation of aerosolized particles. The package may be configured so that the formulation is held in a container not positioned directly vertical to and below the porous membrane, thus making it necessary to channel formulation horizontally to the porous membrane and making it possible to include a vibrating mechanism directly below a chamber covered by the porous membrane. Release of aerosolized drug is breath actuated based on simultaneous measurements of inspiratory flow and volume so as to provide for repeatable dosing of drug to the patient.

Other References

  • Newman et al., "How Should A Pressurized B-Adrenergic Bironchodilator Be Inhaled?", (1981), Eur. J. Respir. Dis., 62:3-21
  • Byron, P.R., ed., Respiratory Drug Delivery CRC Press, Inc., Boca Raton, FL (1990)
  • Newman et al., "Deposition of pressurised aerosis in the human respiratory tract" Thorax (1981) 36:52-55
  • Newman et al., "How should pressurized ଲ-adrenergic bronchodilator be inhaled?" Eur. J. Repir. Dis. (1981) 62:3-21
  • Newman et al., Deposition of pressurized suspension aerosols inhaled through extension devices1-3 Am Rev. Respir. Dis. (1981) 124:37-320
  • Costar.RTM. Life Science Filtration Catalog, "Nucleopore.RTM. Polycarbonate Membranes" (1992) p. 7
  • Harrison's Principles on Internal Medicine, "Diabetes Mellitus" (10th ed. 1983) 666-674
  • Baum, E.A., et al., "A Novel breath actuated piezo electronic inhaler" 3M Healthcare Product Bulletin, 3M House, Morley Street Loughborough. Leic S LE11 1EP, England (1 page total)
  • Newman et al., "Deposition of pressurised aerosols in the lung using radio-labelled particles" Thorax (1980) 35:234
  • Newman et al., "How should a pressurized ଲ-adrengergic bronchodilator be inhaled?" Eur. J. Respir. Dis. (1981) 62:3-2
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