Use of hydrophilic penetration agents in dermatological compositions for the treatment of onychomycoses, and corresponding compositions
September 29, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesPolymeric diffusion matrix Precutaneous absorption accelerator and preparation containing same Compositions comprising 1-substituted azacycloalkanes and their uses Fungicidal compositions and method Delivery systems for pharmaceutical or therapeutic actives Skin permeation enhancer compositions, and methods and transdermal systems associated therewith Medicating device for nails and adjacent tissue Method for delivering an active substance topically or percutaneously Compositions comprising 1-substituted azacycloalkanes Nail lacquer with antimycotic activity, and a process for the preparation thereof Patent #: 5264206 InventorsAssigneeApplicationNo. 381583 filed on 01/30/1995US Classes:424/61, MANICURE OR PEDICURE COMPOSITIONS514/858, Athlete's foot514/947Topical applicationExaminersPrimary: Gardner, SallyAttorney, Agent or FirmForeign Patent References
International ClassesH61K 007/04H61K 007/043 Foreign Application Priority Data1991-03-08 FRAbstractThe hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at least one antifungal agent chosen, in particular, from among those of the allylamine family, such as terbinafine-HCl and naftifine-HCl; at least one hydrophilic penetration agent chosen, in particular, from among the glycols, glycol monoethers, glycol diethers, dimethylsulphoxide, caprolactam, dimethylisosorbide, isopropylidene glycerol, dimethylimidazolidinone, ethyl lactate, the polyoxyethylenated C8 -C10 glycerides, polyethylene glycol 20 glyceryl laurate and dimethylacetamide; and a water-alcohol solvent medium which dissolves the said antifungal agent(s) and in which the said penetration agent(s) is (or are) at least partially miscible. | |
