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Lipid based composition containing diacylglycerol, phospholipid, polar liquid and biologically active material

Patent 5807573 Issued on September 15, 1998. Estimated Expiration Date: Icon_subject November 27, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Galenical compositions
Patent #: 4388307
Issued on: 06/14/1983
Inventor: Cavanak

Method and composition for controlled delivery of biologically active agents
Patent #: 5143934
Issued on: 09/01/1992
Inventor: Lading, et al.

Method of preparing controlled-release preparations for biologically active materials and resulting compositions
Patent #: 5151272
Issued on: 09/29/1992
Inventor: Engstrom, et al.

Lipid vesicles having an alkyd as a wall-forming material
Patent #: 5164191
Issued on: 11/17/1992
Inventor: Tabibi, et al.

Implant material composition, preparation thereof as well as uses thereof and implant product obtainable therefrom
Patent #: 5196201
Issued on: 03/23/1993
Inventor: Larsson, et al.

Sustained release compositions for treating periodontal disease Patent #: 5262164
Issued on: 11/16/1993
Inventor: Damani

Inventors

Assignee

Application

No. 750126 filed on 11/27/1996

US Classes:

424/450Liposomes

Examiners

Primary: Kishore, Gollamudi S.

Attorney, Agent or Firm

Foreign Patent References

  • 0 314 689 EP. 05/13/1989
  • 84/02076 WO. 06/13/1984
  • 92/20377 WO. 11/13/1992

International Class

A61K 037/00

Foreign Application Priority Data

1994-06-15 SE

Abstract

A biologically active composition containing (a) a diacyl glycerol, (b) a phospholipid and, optionally, (c) a polar liquid in such proportions that they together form an L2-phase or a cubic liquid crystalline phase, in which a biologically active material is dissolved or dispersed. A method for preparing the composition by mixing (a), (b) and, optionally, (c) for forming an L2-phase or a cubic liquid crystalline phase, the biologically active material being added before, during or after the formation of said phase. Use of the L2-phase or the cubic liquid crystalline phase for encapsulating a biologically active material for obtaining a preparation is provided, which yields a controlled release of the biologically active material.

Other References

  • Biochemistry, vol. 29, 1990, John M. Seddon, "An Inverse Face-Centered Cubic Phase Formed by Diacylglycerol-Phosphatidylcholine Mixtures", p. 7997
  • "Lipid Polymorphism: A Correction. The structure of the Cubic Phase of Extinction Symbol Fd--Consists of Two Types of Disjointed Reverse Micelles Embedded in a Three-Dimensional Hydrocarbon Matrix", Vittorio Luzzati et al., Biochemistry, 1992, 31, pp. 279-285
  • "Formulation of a Drug Delivery System Based on a Mixture of Monoglycerides and Triglycerides for Use in Treatment of Periodontal Disease", Tomas Norling et al., J. Clin. Periodontal, 1992, 19, pp. 687-69
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