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Method of preparing a forskohlin composition from forskohlin extract and use of forskohlin for promoting lean body mass and treating mood disorders

Patent 5804596 Issued on September 8, 1998. Estimated Expiration Date: Icon_subject February 27, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Assignee

Application

No. 807652 filed on 02/27/1997

US Classes:

514/455Chalcogen bonded directly to ring carbon of the hetero ring

Examiners

Primary: Goldberg, Jerome D.

Attorney, Agent or Firm

International Class

A61K 031/35

Abstract

A method of promoting lean body mass in an individual is disclosed, comprising administering to the individual a lean body mass promoting effective amount of forskohlin. A method of treating a mood disorder is also disclosed, comprising administering to a patient in need thereof a mood disorder treating effective amount of forskohlin. Compositions suitable for promoting lean body mass and/or treating a mood disorder are also disclosed, the composition comprising about 1 to about 40% forskohlin in combination with at least one physiologically acceptable carrier or excipient. A method of preparing a forskohlin composition from a forskohlin extract of Coleus Forskoli plant is further disclosed, as well as a forskohlin composition prepared by the method.

Other References

  • Hoffman, et al., Horm. metabol. Res., 19 (1987) pp. 358-360, "Stimulation and Inhibition of Lipolysis in Isolated Rat Adipocytes: Evidence for Age-Related Changes in Responses . . . "
  • Allen, et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 238, Not. 2, pp. 659-664, "Relationships between cyclic AMP Levels and Lipolysis in Fat Cells After . . . "
  • Allen, et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 244, No. 3, pp. 852-858, "Quantitative Differences in the Cyclic AMP-Lipolysis Relationships for . . . "
  • Wachtel, et al, Psychopharmacology (1986) 90 pp. 430-435, "Effects of forskolin and cyclic nucleotides in animal models predictive of antidepressant activity: interactions with rolipram
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