Cyclohexanone extraction of 3-hydroxymethylcephalosporins
July 18, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3573296 3830809 3835129 Pentavalent phosphorus amides of cephalosporins and separation process using same Dispensing pump Process for the recovery of cephalosporin C and derivatives thereof Production of a cephalosporin by fermentation Method of producing cephem compounds Acetylation of 3-hydroxymethyl cephalosporins Enzymatic process for preparing 7-aminocephalosporanic acid and derivatives Patent #: 5424196 InventorsAssigneeApplicationNo. 896377 filed on 07/18/1997US Classes:540/230Alkyl, hydroxyalkyl, alkoxyalkyl or alkanoyloxyalkyl bonded directly to 3 positionExaminersPrimary: Berch, Mark L.Attorney, Agent or FirmForeign Patent References
International ClassC07D 501/28ClaimsWe claim: 1. A process for preparing a concentrated (≥10% weight/volume) aqueous solution of desacetyl 7-glutaryl ACA from an aqueous solution containing the desacetyl 7-glutaryl ACA in lower concentration, which comprises the steps of: (a) providing an aqueous solution containing desacetyl 7-glutaryl ACA; (b) contacting the solution with cyclohexanone at a pH of from about 1.5 to about 3 so as to extract the desacetyl 7-glutaryl ACA into the cyclohexanone solvent phase; (c) separating the cyclohexanone solvent phase from the aqueous phase: (d) contacting the cyclohexanone phase with water at a pH of from about 5 to about 7.5; and (e) separating the aqueous phase containing the desired concentrated solution of desacetyl 7-glutaryl ACA. 2. The process of claim 1 wherein the aqueous solution in Step (a) is a processed fermentation broth. 3. The process of claim 1 or claim 2 wherein Step(d) includes use of an acetate buffer. 4. A process for preparing a concentrated (≥10% weight/volume) aqueous solution of desacetyl cephalosporin D from an aqueous solution containing the desacetyl cephalosporin D in lower concentration, which comprises the steps of (a) providing an aqueous solution containing desacetyl cephalosporin D; (b) contacting the solution with cyclohexanone at a pH of from about 1.5 to about 3 so as to extract the desacetyl cephalosporin D into the cyclohexanone solvent phase; (c) separating the cyclohexanone solvent phase from the aqueous phase; (d) contacting the cyclohexanone phase with water at a pH of from about 5 to about 7.5; and (e) separating the aqueous phase containing the desired concentrated solution of desacetyl cephalosporin D. 5. The process of claim 4 wherein the aqueous solution in step (a) is a processed fermentation broth. 6. The process of claim 4 or claim 5 wherein step (d) includes use of an acetate buffer. Other References
|
| ||||||||||||||
