Liquisolid systems and methods of preparing same
Patent 5800834 Issued on September 1, 1998. Estimated Expiration Date: 
June 10, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 10, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsApplicationNo. 658514 filed on 06/10/1996US Classes:424/451, Capsules (e.g., of gelatin, of chocolate, etc.)264/5, FORMATION OF SOLID PARTICULATE MATERIAL DIRECTLY FROM MOLTEN OR LIQUID MASS (E.G., LIQUID COMMINUTING)264/6, With subsequent uniting of the particles264/7, Coated particles264/40.4, Measuring a weight or volume (e.g., level-responsive, etc.)424/456, Gelatin424/457, Sustained or differential release424/458, Containing discrete coated particles pellets, granules, or beads424/459, Organic coatings424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/462, Containing solid synthetic polymers424/464, Tablets, lozenges, or pills424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/468, Sustained or differential release type424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/490, Coated (e.g., microcapsules)424/493, Containing polysaccharides (e.g., sugars)424/494, Cellulose derivatives424/497, Containing solid synthetic polymers424/501Contains solid synthetic resinExaminersPrimary: Krass, FrederickAttorney, Agent or FirmInternational ClassA61K 009/20AbstractLiquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. According to the concept of liquisolid systems, liquid lipophilic drugs, or water-insoluble solid drugs dissolved in suitable non-volatile solvents, may be converted into free-flowing and readily compressible powders by a simple admixture with selected powder excipients referred to as the carrier and coating materials. Various grades of microcrystalline or amorphous cellulose may be used as carriers, whereas very fine particle size silica powders may be used as coating materials. Based on the theory that the carrier and coating materials can retain only certain amounts of liquid and at the same time maintain acceptable flow and compression properties, a new formulation-mathematical model is provided to calculate the optimum quantities of carrier and coating materials required to yield acceptably flowing and compressible liquid/powder admixtures.Other References
Field of SearchFORMATION OF SOLID PARTICULATE MATERIAL DIRECTLY FROM MOLTEN OR LIQUID MASS (E.G., LIQUID COMMINUTING)With subsequent uniting of the particles Coated particles Measuring a weight or volume (e.g., level-responsive, etc.) Capsules (e.g., of gelatin, of chocolate, etc.) With claimed designated perfecting feature in contents (e.g., excipient, lubricant, etc.) Gelatin Sustained or differential release Containing discrete coated particles pellets, granules, or beads Organic coatings Containing polysaccharide (e.g., cellulose sugars, etc.) Containing solid synthetic polymers Tablets, lozenges, or pills With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.) Sustained or differential release type Particulate form (e.g., powders, granules, beads, microcapsules, and pellets) Coated (e.g., microcapsules) Containing polysaccharides (e.g., sugars) Cellulose derivatives Containing solid synthetic polymers Contains solid synthetic resin | |
