Bioresponsive pharmacologically-active polymers and articles made therefrom
February 13, 2017. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References7-amino-1-cyclopropyl-4-oxo-1, 4-dihydro-quinoline-and naphthyridine-3-carboxylic acids and antibacterial agents containing these compounds Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders Amplification of the VB12 uptake system using polymers Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells Patent #: 5474765 InventorsApplicationNo. 799938 filed on 02/13/1997US Classes:424/423, Surgical implant or material424/78.08, SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)604/29, Peritoneal dialysis606/228Suture or ligatureExaminersPrimary: Kulkosky, Peter F.Attorney, Agent or FirmForeign Patent References
International ClassA61K 031/785AbstractThis invention relates to pharmacologically-active polymeric compounds; to substrates, such as implantable medical devices formed thereof or coated therewith; and to methods of using said compounds or said substrates for providing pharmacological agents released in response to in vivo activation at a desired location in a mammal. The polymeric material has a backbone comprising a pharmacologically-active fragment covalently linked through at least two functional groups within the backbone, wherein the backbone comprises, preferably, polyamide, polyurethane and/or polyurea linkages with, optionally, polyester, polycarbonate, polyether and/or polyvinyl linkages. The preferred pharmacological compounds are fluoroquinolines, particularly, ciprofloxacin. The pharmacologically-active compounds provide in vivo enhanced long term anti-inflammatory, anti-bacterial, anti-microbial and/or anti-fungal activity.Other References
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