Apparatus for Simulating a High Five
A self-righting hand-arm configuration which is adapted to pivot when struck by a user, thereby simulating a "high five."
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AbstractThis invention relates to pharmacologically-active polymeric compounds; to substrates, such as implantable medical devices formed thereof or coated therewith; and to methods of using said compounds or said substrates for providing pharmacological agents released in response to in vivo activation at a desired location in a mammal. The polymeric material has a backbone comprising a pharmacologically-active fragment covalently linked through at least two functional groups within the backbone, wherein the backbone comprises, preferably, polyamide, polyurethane and/or polyurea linkages with, optionally, polyester, polycarbonate, polyether and/or polyvinyl linkages. The preferred pharmacological compounds are fluoroquinolines, particularly, ciprofloxacin. The pharmacologically-active compounds provide in vivo enhanced long term anti-inflammatory, anti-bacterial, anti-microbial and/or anti-fungal activity.Other References
| InventorsApplicationNo. 799938 filed on 02/13/1997US Classes:424/423, Surgical implant or material424/78.08, SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)604/29, Peritoneal dialysis606/228Suture or ligatureField of Search424/78.08, SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)424/78.27, Nitrogen or sulfur424/423Surgical implant or materialExaminersPrimary: Kulkosky, Peter F.Attorney, Agent or FirmUS Patent References4670444, 7-amino-1-cyclopropyl-4-oxo-1, 4-dihydro-quinoline-and naphthyridine-3-carboxylic acids and antibacterial agents containing these compoundsIssued on: 06/02/1987 Inventor: Grohe , et al.5219564, Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon Issued on: 06/15/1993 Inventor: Zalipsky, et al.5405919, Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders Issued on: 04/11/1995 Inventor: Keefer, et al.5449720, Amplification of the VB12 uptake system using polymers Issued on: 09/12/1995 Inventor: Russell-Jones, et al.5455027, Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon Issued on: 10/03/1995 Inventor: Zalipsky, et al.5474765Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells Issued on: 12/12/1995 Inventor: Thorpe Foreign Patent References
International ClassA61K 031/785 |