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US Patent 5798115 - Bioresponsive pharmacologically-active polymers and articles made therefrom

US Patent Issued on August 25, 1998
Estimated Patent Expiration Date: Icon_subject February 13, 2017Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

This invention relates to pharmacologically-active polymeric compounds; to substrates, such as implantable medical devices formed thereof or coated therewith; and to methods of using said compounds or said substrates for providing pharmacological agents released in response to in vivo activation at a desired location in a mammal. The polymeric material has a backbone comprising a pharmacologically-active fragment covalently linked through at least two functional groups within the backbone, wherein the backbone comprises, preferably, polyamide, polyurethane and/or polyurea linkages with, optionally, polyester, polycarbonate, polyether and/or polyvinyl linkages. The preferred pharmacological compounds are fluoroquinolines, particularly, ciprofloxacin. The pharmacologically-active compounds provide in vivo enhanced long term anti-inflammatory, anti-bacterial, anti-microbial and/or anti-fungal activity.

Other References

  • Shi et al: Synthesis and Characterization of Hydrolytically Labile Poly (phosphoester-urethanes) American Chemical Society (1991) pp. 141-154, Chapter 14
  • Bruin et al: "Biodegradable lysine diisocyanate-based poly (glycolide-co-&3xb5;-caprolactone)-urethane network in artificial skin"
  • Jansen et al: "Development of polymers with anti-infectious properties", Applied Bioactive Polymeric Materials, 1987 Polymer . . . Technology, 38, pp. 97-113
  • Jansen et al: "Antibiotic-containing polyurethanes for the prevention of foreign-body infections", Polymeric Materials Science & Engineering, 1988, 59, 794-797
  • Golomb et al: "Prevention of bacterial coloization on polyurethane in vitro by incorporated antibacterial agent", Journal of Biomedical Materials Research, vol. 25, 937-952 (1991)
  • Phaneuf et al: "Application of the quinolone antibiotic ciprofloxacin to Dacron utilizing textile dyeing technology", Journal of Biomedical Materials Research, vol
  • Ozaki et al: "In Vivo Testing of an Infection-Resistant Vascular Graft Material", Journal of Surgical Research 55, 543-547 (1993)
  • Karck et al: "The Efficacy of Controlled Antibiotic Release for Prevention of Polyethyleneterephthalate-(Dacron-) Related Infection in Cardiovascular Surgery", Clinical Materials 13 (1993) 149-154
  • Duran et al: "Antimicrobial coatings on medial devices", Surfaces In Biomaterials Symposium, Oct. 14-16, 1992
  • Ghosh:, "Synthetic Macromolecules as Potential Chemotherapeutic Agents", Polymers News 1988, vol. 13, pp. 71-77
  • Veld, et al: "In-vitro Degradation of Polyesteramides Containing Poly-&3xb5;-caprolactone Blocks", Clinical Materials 13, 1993, 143-147
  • Ghosh: Studies Directed Towards Polymeric Quinolone Antibiotics -Synthesis of Potential Monomers From Nalidixic Acid, pp. 790-793
  • Ghosh;, "Monomers and polymers from nalidixic acid -synthesis, characterization and hydrolysis study", Process In Biomedical Polymers, 1990, pp. 335-345
  • Santerre et al, Macromolecules, 24:5497-5503 (1991); Santerre et al, Journal of Biomedical Materials Research, 28:1167-1199 (1994)
  • Phaneuf et al, Journal of Biomedical Materials Research, 27:233-237 (1993)
  • Blassberger et al, Biotechnology and Bioengineering, XX:309-315 (1978)
  • Labow et al, J. Biomater. Sci. Polymer, Edn. 6(2):169-179 (1994)
  • Poiani et al, Bioconjugate Chemistry, 5(6):621-629 (1994

Inventors

Application

No. 799938 filed on 02/13/1997

US Classes:

424/423, Surgical implant or material424/78.08, SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)604/29, Peritoneal dialysis606/228Suture or ligature

Field of Search

424/78.08, SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)424/78.27, Nitrogen or sulfur424/423Surgical implant or material

Examiners

Primary: Kulkosky, Peter F.

Attorney, Agent or Firm

US Patent References

4670444, 7-amino-1-cyclopropyl-4-oxo-1, 4-dihydro-quinoline-and naphthyridine-3-carboxylic acids and antibacterial agents containing these compounds
Issued on: 06/02/1987
Inventor: Grohe ,   et al.
5219564, Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
Issued on: 06/15/1993
Inventor: Zalipsky, et al.
5405919, Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
Issued on: 04/11/1995
Inventor: Keefer, et al.
5449720, Amplification of the VB12 uptake system using polymers
Issued on: 09/12/1995
Inventor: Russell-Jones, et al.
5455027, Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
Issued on: 10/03/1995
Inventor: Zalipsky, et al.
5474765Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
Issued on: 12/12/1995
Inventor: Thorpe

Foreign Patent References

  • 0 710 689 A2 EP 05/21/1996

International Class

A61K 031/785

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