High level expression of proteins
Patent 5795737 Issued on August 18, 1998. Estimated Expiration Date: 
September 22, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 22, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesManufacture and expression of structural genes Codon pair utilization Cancer-associated SCM-recognition factor, preparation and method of use Phosphinothricin-resistance gene, and its use Cloned genes encoding reverse transcriptase lacking RNase H activity Bovine basic fibroblast growth factor Patent #: 5464774 InventorsAssigneeApplicationNo. 532390 filed on 09/22/1995US Classes:435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide435/183, ENZYME (E.G., LIGASES (6. ), ETC.), PROENZYME; COMPOSITIONS THEREOF; PROCESS FOR PREPARING, ACTIVATING, INHIBITING, SEPARATING, OR PURIFYING ENZYMES435/252.3, Transformants (e.g., recombinant DNA or vector or foreign or exogenous gene containing, fused bacteria, etc.)435/254.11, Transformants435/254.2, Yeast; media therefor536/23.1, DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)536/23.5Encodes an animal polypeptideExaminersPrimary: Wax, Robert A.Assistant: Longton, Enrique D. Attorney, Agent or FirmForeign Patent References
International ClassC12N 015/00AbstractThe invention features a synthetic gene encoding a protein normally expressed in a mammalian cell or eukaryotic cell wherein at least one non-preferred or less preferred codon in the natural gene encoding the mammalian protein has been replaced by a preferred codon encoding the same amino acid.Other References
Field of SearchEncodes an animal polypeptideDNA or RNA fragments or modified forms thereof (e.g., genes, etc.) VECTOR, PER SE (E.G., PLASMID, HYBRID PLASMID, COSMID, VIRAL VECTOR, BACTERIOPHAGE VECTOR, ETC.) BACTERIOPHAGE VECTOR, ETC.) Transformants (e.g., recombinant DNA or vector or foreign or exogenous gene containing, fused bacteria, etc.) Transformants Yeast; media therefor ENZYME (E.G., LIGASES (6. ), ETC.), PROENZYME; COMPOSITIONS THEREOF; PROCESS FOR PREPARING, ACTIVATING, INHIBITING, SEPARATING, OR PURIFYING ENZYMES Recombinant DNA technique included in method of making a protein or polypeptide |
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