U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method for preparing recombinant adeno-associated viruses (AAV), and uses thereof

Patent 5789390 Issued on August 4, 1998. Estimated Expiration Date: Icon_subject July 25, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

AAV transduction vectors
Patent #: 5139941
Issued on: 08/18/1992
Inventor: Muzyczka, et al.

Production of recombinant adeno-associated virus vectors Patent #: 5354678
Issued on: 10/11/1994
Inventor: Lebkowski, et al.

Inventors

Assignee

Application

No. 682520 filed on 07/25/1996

US Classes:

514/44, Polynucleotide (e.g., RNA, DNA, etc.)424/199.1, Recombinant virus encoding one or more heterologous proteins or fragments thereof424/233.1, Adenoviridae, adeno-like virus, or Parvoviridae (e.g., adenovirus, canine parvovirus, mink enteritis virus, hemorrhagic enteritis virus, feline panleukopenia virus, egg drop syndrome virus, etc.)435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide435/235.1, VIRUS OR BACTERIOPHAGE, EXCEPT FOR VIRAL VECTOR OR BACTERIOPHAGE VECTOR; COMPOSITION THEREOF; PREPARATION OR PURIFICATION THEREOF; PRODUCTION OF VIRAL SUBUNITS; MEDIA FOR PROPAGATING536/23.5Encodes an animal polypeptide

Examiners

Primary: Achutamurthy, Ponnathapu
Assistant: Bui, Hung

Foreign Patent References

  • 0488528A1 EP. 06/21/1992
  • WO91/18088 WO. 11/21/1991

International Classes

A61K 039/235
C12N 007/01
C12P 021/00
C07H 021/04

Foreign Application Priority Data

1994-01-28 FR

Abstract

A novel method for preparing vectors derived from adeno-associated viruses (AAV), cells used therefor, and the use of the resulting vectors, particularly in gene and/or cell therapy, are disclosed.

Other References

  • Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, Dec. 7, 1995 Coglan, New Scientist, 25 Nov. 1995, pp. 14-15
  • Spibey et al. J Gen Virol, vol. 70, 1989, pp. 165-172
  • Cukor et al., Biology of Adeno-Associated Virus, The Parvoviruses, Plenum 33-66 (1984)
  • Hermonat et al., Use of adeno-associated virus as a mammalian DNA cloning vector: Transduction of neomycin resistance into mammalian tissue culture cells, Proc. Natl. Acad. Sci. USA, 81, 6466-6470 (1984)
  • Bauer et al., Growth of avian adeno-associated virus in chicken cells transfected with fowl adenovirus serotype 1 DNA, Journal of Virological Methods, 29, 335-340 (1990)
  • Bauer et al., Herpesviruses Provide Helper Functions for Avian Adeno-associated Parvovirus, J. Gen. Virol. 67, 181-185 (1986)
  • Georg-Fries et al., Analysis of Proteins, Helper Dependence, and Seroepidemiology of a New Human Parvovirus, Virology 134, 61-71 (1984)
  • Schlehofer et al., Vaccinia Virus, Herpes Simplex Virus, and Carcinogens Induce DNA Amplification in a Human Cell Line and Support Replication of a Helpervirus Dependent Parvovirus, Virology 152, 110-117 (1986)
  • Flotte et al., Adeno-Associated Virus Vectors for In Vivo Gene Transfer, Journal of Cellular Biochemistry, Supp, 18A, 214 (1994
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
 
Sign InRegister
Username  
Password   
forgot password?