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US Patent 5789385 - Sialyl Lewisx mimetics containing phenyl backbones

US Patent Issued on August 4, 1998
Estimated Patent Expiration Date: Icon_subject February 21, 2016Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

Compounds that possess selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs, derivatives, or mimics of these groups, such that sialic acid and fucose or their mimics are separated by a linker that permits binding between those groups and the selecting, such compounds being represented by the following general structural formula I: ##STR1##

Other References

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Inventors

Assignee

Application

No. 604162 filed on 02/21/1996

US Classes:

514/25, O-glycoside514/24, S-glycoside514/42, N-glycoside536/4.1, O- or S- Glycosides536/17.2, Nitrogen containing536/17.5, Sulfur containing (e.g., methylthiolincosaminide, etc.)536/17.9Nitrogen in aglycone moiety

Field of Search

514/24, S-glycoside514/25, O-glycoside514/42, N-glycoside536/4.1, O- or S- Glycosides536/17.2, Nitrogen containing536/17.5, Sulfur containing (e.g., methylthiolincosaminide, etc.)536/17.9Nitrogen in aglycone moiety

Examiners

Primary: Fonda, Kathleen K.

Attorney, Agent or Firm

US Patent References

4849513, Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
Issued on: 07/18/1989
Inventor: Smith ,   et al.
5138044, Synthesis of sialosides
Issued on: 08/11/1992
Inventor: Dasgupta
5143712, Method of determining a site of inflammation utilizing elam-1 ligands
Issued on: 09/01/1992
Inventor: Brandley, et al.
5211937, Method of determining a site of inflammation utilizing ELAM-1 ligands
Issued on: 05/18/1993
Inventor: Brandley, et al.
5296594, Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
Issued on: 03/22/1994
Inventor: Ratcliffe, et al.
5316913, Neutrophil LECAM-1 as indicator of neutrophil activation
Issued on: 05/31/1994
Inventor: Butcher, et al.
5318890, Assays for inhibitors of leukocyte adhesion
Issued on: 06/07/1994
Inventor: Rosen, et al.
5527890Derivatives of triterpenoid acids and uses thereof
Issued on: 06/18/1996
Inventor: Rao, et al.

Foreign Patent References

  • 9013300 WO. 11/12/1990
  • 9107993 WO. 06/12/1991
  • 9119501 WO. 12/12/1991
  • 9119502 WO. 12/12/1991
  • 9207572 WO. 05/12/1992
  • 9209293 WO. 06/12/1992
  • 9214757 WO. 09/12/1992
  • 9216612 WO. 10/12/1992
  • 9218610 WO. 10/12/1992
  • 9300908 WO. 01/12/1993
  • 9300919 WO. 01/12/1993
  • 9408051 WO. 04/12/1994
  • 9411030 WO. 05/12/1994
  • 9424145 WO. 10/12/1994
  • 9503315 WO. 02/12/1995
  • 9636627 WO. 11/12/1996

International Classes

A61K 031/70
C07H 015/00

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