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Overexpression of mammalian and viral proteins

Patent 5786464 Issued on July 28, 1998. Estimated Expiration Date: Icon_subject July 28, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Manufacture and expression of structural genes
Patent #: 4652639
Issued on: 03/24/1987
Inventor: Stabinsky

Codon pair utilization
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Issued on: 01/21/1992
Inventor: Hatfield, et al.

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Inventor

Assignee

Application

No. 324243 filed on 09/19/1994

US Classes:

536/23.5, Encodes an animal polypeptide435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide435/91.5, Acellular preparation of polynucleotide435/252.3, Transformants (e.g., recombinant DNA or vector or foreign or exogenous gene containing, fused bacteria, etc.)536/23.72Viral protein

Examiners

Primary: Wax, Robert A.
Assistant: Moore, William W.

Attorney, Agent or Firm

International Classes

C12N 015/11
C12N 015/12
C12N 015/48
C12P 019/34

Abstract

The invention features a synthetic gene encoding a protein normally expressed in mammalian cells wherein at least one non-preferred or less preferred codon in the natural gene encoding the mammalian protein has been replaced by a preferred codon encoding the same amino acid.

Other References

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