Boronophenyl analogs of phospholyrosines
Patent 5776902 Issued on July 7, 1998. Estimated Expiration Date: 
July 7, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 7, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorAssigneeApplicationNo. 454920 filed on 05/31/1995US Classes:514/18, 3 or 4 peptide repeating units in known peptide chain514/19, 2 peptide repeating units in known peptide chain530/330, 4 to 5 amino acid residues in defined sequence530/331, Tripeptides, e.g., tripeptide thyroliberin (TRH), melanostatin (MIF), etc.556/7, Boron containing564/152, Plural carboxamide groups containing or containing plural carbonyls bonded directly to the same nitrogen564/153Three or more carboxamide groupsExaminersPrimary: Gupta, Yogendra N.Attorney, Agent or FirmInternational ClassesA61K 038/05A61K 038/07 C07K 005/06 C07K 005/08 AbstractThe present invention makes available novel compounds useful for inhibiting kinases, phosphatases and SH2 domains, e.g., an interaction between a protein containing an SH2 domain and a phophotyrosine-containing polypeptide. In one embodiment, the present invention provides boronylphenyl analogs of phosphotyrosines which, in such forms as peptidomimetics, can be used to modulate signal transduction pathways in cells.Other References
Field of Search3 or 4 peptide repeating units in known peptide chain2 peptide repeating units in known peptide chain Tripeptides, e.g., tripeptide thyroliberin (TRH), melanostatin (MIF), etc. 4 to 5 amino acid residues in defined sequence Boron containing Plural carboxamide groups containing or containing plural carbonyls bonded directly to the same nitrogen Three or more carboxamide groups |
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