U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Flunisolide aerosol formulations

Patent 5776433 Issued on July 7, 1998. Estimated Expiration Date: Icon_subject July 7, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2868691

2885427

Aerosol composition
Patent #: 4083954
Issued on: 04/11/1978
Inventor: Tsuchiya, et al.

Aerosol propellant compositions
Patent #: 4174295
Issued on: 11/13/1979
Inventor: Bargigia ,   et al.

Pressurized aerosol formulation and process for the manufacture thereof
Patent #: 4243548
Issued on: 01/06/1981
Inventor: Heeb ,   et al.

Process for preparing flunisolide
Patent #: 4273710
Issued on: 06/16/1981
Inventor: Jones ,   et al.

Drug-containing chlorofluorocarbon aerosol propellent formulations
Patent #: 4814161
Issued on: 03/21/1989
Inventor: Jinks ,   et al.

LHRH analog formulations
Patent #: 4851211
Issued on: 07/25/1989
Inventor: Adjei ,   et al.

Stable, crystalline flunisolide
Patent #: 4933168
Issued on: 06/12/1990
Inventor: Jones, et al.

Refrigerants
Patent #: 4983312
Issued on: 01/08/1991
Inventor: Tamura, et al.

More ...

Inventors

Application

No. 456029 filed on 05/31/1995

US Classes:

424/45, Organic pressurized fluid424/46Powder or dust containing

Examiners

Primary: Bawa, Raj

Attorney, Agent or Firm

Foreign Patent References

  • 12188/92 AU. 09/12/1992
  • 0384371 A1 EP. 08/12/1990
  • 0504112 A2 EP. 09/12/1992
  • 518601 EP. 12/12/1992
  • 4123663 A1 DE. 01/12/1993
  • 91/11496 WO. 08/12/1991
  • 91/11495 WO. 08/12/1991
  • 91/14422 WO. 10/12/1991
  • 92/06675 WO. 04/12/1992
  • 92/22288 WO. 12/12/1992
  • 92/22287 WO. 12/12/1992
  • 93/11747 WO. 06/12/1993

International Class

A61K 009/12

Abstract

Pharmaceutical aerosol formulations substantially free of chlorofluorocarbons and comprising a therapeutically effective amount of flunisolide in solution with ethanol and a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane and a mixture thereof are used for the treatment of bronchial asthma. The formulation may be delivered by a metered dose inhaler with a canister that is inert to flunisolide.

Other References

  • Gennaro, A. R. (1985). Remington's Pharmaceutical Sciences. Mack Publishing Co., pp. 1670-1677
  • Moren, F. et al. (1993). Aerosols in Medicine: Princples, Deagnosis and Therapy. Elsevier, pp. 303-319
  • The Theory and Practice of Industrial Pharmacy, Leon Lachman et al., 3rd Ed., Lea & Febiger 1986, Chapter 20, pp. 597, 599 and 603
  • The Theory and Practice of Industrial Pharmacy, 2nd Edition, 1976, Lea & Febiger, Philadelphia, pp. 270 and 276-28
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