U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Compounds and peptides that bind to the erythropoietin receptor

Patent 5773569 Issued on June 30, 1998. Estimated Expiration Date: Icon_subject June 30, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method for the purification of erythropoietin and erythropoietin compositions
Patent #: 4677195
Issued on: 06/30/1987
Inventor: Hewick ,   et al.

DNA sequences encoding erythropoietin
Patent #: 4703008
Issued on: 10/27/1987
Inventor: Lin

Erythropoietin (EPO) peptides
Patent #: 5106954
Issued on: 04/21/1992
Inventor: Fibi, et al.

Recombinant DNA endoding an erythropoietin receptor
Patent #: 5278065
Issued on: 01/11/1994
Inventor: D'Andrea, et al.

Homogeneous erythropoietin compositions and methods of using same
Patent #: 5322837
Issued on: 06/21/1994
Inventor: Hewick, et al.

In-vitro method for determining a surreptitious use of exogenous erythropoiesis stimulating agents by a normal living subject
Patent #: 5369014
Issued on: 11/29/1994
Inventor: Brugnara, et al.

Enhancer for the antianemia effect of erythropoietin and method of augmenting the antianemia effect of erythropoietin
Patent #: 5399551
Issued on: 03/21/1995
Inventor: Ise, et al.

Proteinaceous compositions having an activity on erythropoiesis Patent #: 5482924
Issued on: 01/09/1996
Inventor: Royet, et al.

Inventors

Assignee

Application

No. 484635 filed on 06/07/1995

US Classes:

530/300, PEPTIDES OF 3 TO 100 AMINO ACID RESIDUES435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide530/324, 25 or more amino acid residues in defined sequence530/325, 24 amino acid residues in defined sequence530/326, 15 to 23 amino acid residues in defined sequence530/327, 11 to 14 amino acid residues in defined sequence530/3288 to 10 amino acid residues in defined sequence

Examiners

Primary: Jagannathan, Vasu S.
Assistant: Kemmerer, Elizabeth

Attorney, Agent or Firm

Foreign Patent References

  • 2021528 CA. 01/13/1991
  • 0 428 267 EP. 05/13/1991
  • 0 427 189 EP. 05/13/1991
  • WO 90/08822 WO. 08/13/1990
  • WO 91/05867 WO. 05/13/1991
  • WO 93/25221 WO. 12/13/1993
  • WO 94/02611 WO. 02/13/1994
  • 9640749 WO 12/13/1996
  • 9640772 WO 12/13/1996

International Classes

C07K 007/00
C12N 015/09

Abstract

Peptides of 10 to 40 or more amino acid residues in length and having the sequence X3 X4 X5 GPX6 TWX7 X8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter abbreviation; X3 is C; X4 is R, H, L, or W; X5 is M, F, or I; X6 is independently selected from any one of the 20 genetically coded L-amino acids; X7 is D, E, I, L, or V; and X8 is C, which bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist, and methods for their use.

Other References

  • Barker, Peter L., et al. (1992) "Cyclic RGD Peptide Analogues as Antiplatelet Antithrombotics", J. Med, Chem., 35:2040-2048
  • Or, Yat Sun, et al. (1991) "Cysteine Alkylation in Unprotected Peptides: Synthesis of a Carbavasopressin Analogue by Intramolecular Cysteine Alkylation", J. Org. Chem. 56:3146-3149
  • Sawyer, Stephen T., et al. (1987) "Binding and Receptor-mediated Endocytosis of Erythropoietin in Friend Virus-infected Erythroid Cells", The Journal of Biological Chemistry, 262(12):5554-5562
  • Sasaki, Hiroshi, et al. (1987) "Carbohydrate Structure of Erythropoietin Expressed in Chinese Hamster Ovary Cells by a Human Erythorpoietin cDNA", The Journal of Biological Chemistry, 262(25):12059-12076
  • Sawyer, Stephen, T., et al. (1987) "Identification of the receptor for erythropoietin by cross-linking to Friend virus-infected erythroid cells", Proc. Natl. Acad. Sci. USA, 84:3690-3694
  • Landschulz, Katherine T., et al. (1989) "Erythropoietin Receptors on Murine Erythroid Colony-Forming Units: Natural History", Blood, 73(6):1476-1486
  • Kitamura, Toshio, et al. (1989) "Identification and Analysis of Human Erythroipoietin Receptors on a Factor-Dependent Cell Line, TF-1", Blood, 73(2):375-380
  • Krystal, Gerald (1983) "A Simple Microassay for Erythropoietin Based on 3 H-Thymidine Incorporation into Spleen Cells from Phenylhydrazine Treated Mice", Exp. Hematol., 11(7):649-660
  • Cwirla, Steven E., et al. (1990) "Peptides on phage: A vast library of peptides for identifying ligands", Proc. Natl. Acad. Sci. USA, 87:6378-6382
  • Bowie, James U., et al. (1990) "Deciphering the Messaging in Protein Sequencing: Tolerance to Amino Acid Substitutions", Science, 247:1306-1310
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
 
Sign InRegister
Username  
Password   
forgot password?