Solid matrix system for transdermal drug delivery

Patent 5770219 Issued on June 23, 1998. Estimated Expiration Date:

June 23, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Acrylic-type pressure sensitive adhesives by means of ultraviolet radiation curing
Patent #: 4181752
Issued on: 01/01/1980
Inventor: Martens , et al.

Depot body on the basis of silicone rubber and process for the preparation thereof
Patent #: 4331651
Issued on: 05/25/1982
Inventor: Reul , et al.

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Inventors

Assignee

Cygnus, Inc.

Application

No. 311914 filed on 09/26/1994

US Classes:

424/448Pressure sensitive adhesive means

Examiners

Primary: Phelan, D. Gabrielle

Attorney, Agent or Firm

Morrison & Foerster LLP

Foreign Patent References

1 255 592 CA. 06/13/1989
1312800 CA. 01/13/1993
0 156 080 EP. 10/13/1985
0 209 975 EP. 01/13/1987
0 223 524 EP. 05/13/1987
0 252 712 EP. 01/13/1988
275716 EP. 07/13/1988
0 328 806 EP. 08/13/1989
0379045 EP. 07/13/1990
0186019 EP. 10/13/1993
57-142258 JP. 09/13/1982
57-179271 JP. 11/13/1982
60-66759 JP. 04/13/1985
60-123417 JP. 07/13/1985
7-101853 JP. 04/13/1995
153637 NO. 11/13/1980
171950 NO. 03/13/1986
2 086 224 GB. 05/13/1982
86/00814 WO. 02/13/1986
87/03477 WO. 06/13/1987
89/07951 WO. 09/13/1989
90/07940 WO. 07/13/1990
93/20165 WO. 10/13/1993
97/23205 WO. 07/13/1997

International Class

A61F 013/02

Abstract

A matrix for containing drugs for transdermal delivery systems is disclosed. The matrix, formed of a skin-adhesive acrylate copolymer, attains high rates of drug delivery without the addition of drug delivery rate enhancers. In preferred embodiments the matrix is used to administer steroids, in particular estradiol. Water-soluble polymers may be added as well.

Other References

Translation of Japanese laid-open patent publ. No. 7-101853, laid-open publ. date Apr. 18, 1995
Abstract of Japanese Patent No. 6-279266 from Derwent World Patent Index, Oct. 4, 1994
Abstract of Japanese Patent No. 4-368322 from Derwent World Patent Index, Jun. 12, 1991
Megrab et al. "Oestradiol permeation through human skin and silastic membrane: effects of propylene glycol and supersaturation" J. Controlled Release (1995) 36:277-294
English Abstract of Japanese Laid-Open Patent Publication Number 57-075917. Laid-Open Publication Date: May 12, 1982
English Abstract of Japanese Laid-Open Patent Publication Number 61-151122. Laid-Open Publication Date: Jul. 9, 1986
Kligman et al., "Preparation of isolated sheets of human stratum corneum" Arch. Dermatol. (1963) 88:702-705
Nitto Electric Industrial Co., Ltd., "Transdermal analgesic tapes" Chemical Abstracts (1985) 102:354 (Abstract 154817h)
Translation of Japanese Laid-Open Patent Publication Number 60-66759. Laid-Open Publication Date: Apr. 16, 1985
Translation of Japanese Laid-Open Patent Publication Number 60-123417. Laid-Open Publication Date: Jul. 2, 1985
Wolff, "In vitro models in the development of transdermal drug delivery systems and their practical relevance for in vivo transdermal absorption" Transdermal Drug Delivery Jaeger et al., eds., Neu-Ulm Conference (1986) pp. 68-7