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Derivatives of triterpenoid acids and uses thereof

Patent 5763582 Issued on June 9, 1998. Estimated Expiration Date: Icon_subject June 9, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3070623

3070624

18ଲ-Glycyrrhetinic acid amides useful as antiulcer agents
Patent #: 3934027
Issued on: 01/20/1976
Inventor: Hess ,   et al.

3ଲ-Hydroxy-18ଲ-olean-9-en-30-oic acids
Patent #: 4173648
Issued on: 11/06/1979
Inventor: Pifferi ,   et al.

Complexes of glycerrhetinic acid with phospholipids and pharmaceutical and cosmetic compositions containing them
Patent #: 5147859
Issued on: 09/15/1992
Inventor: Bombardelli, et al.

Glycyrrhetic acid derivatives
Patent #: 5229378
Issued on: 07/20/1993
Inventor: Ogata, et al.

Method for inhibiting selectin-dependent adhesion of leukocytes and platelets by O-glycosylation modification
Patent #: 5268364
Issued on: 12/07/1993
Inventor: Kojima, et al.

Glycyrrhetinic acid derivatives
Patent #: 5356880
Issued on: 10/18/1994
Inventor: Kurono, et al.

Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin)
Patent #: 5519008
Issued on: 05/21/1996
Inventor: Rao, et al.

Derivatives of triterpenoid acids and uses thereof
Patent #: 5527890
Issued on: 06/18/1996
Inventor: Rao, et al.

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Inventors

Assignee

Application

No. 466843 filed on 06/06/1995

US Classes:

536/5, Cyclopentanohydrophenanthrene ring system536/18.5Processes

Examiners

Primary: Kight, John
Assistant: Lee, Howard C.

Attorney, Agent or Firm

Foreign Patent References

  • 9309129A AU. 05/08/1993
  • 0518533 EP. 05/08/1992
  • 515159A1 EP. 11/08/1992
  • 518533A1 EP. 12/08/1992
  • 9212991A1 JP. 08/08/1992
  • 04290846 JP. 10/08/1992
  • 92068296 JP. 10/08/1992

International Classes

C07H 015/256
C07H 001/00

Abstract

Triterpenoid acid derivatives are described that exhibit dual pharmacophobic activities, specifically selectin ligand and leukotriene biosynthetic inhibitory activities, and that thus have significant applications for the treatment or prevention of certain diseases including cancer and diseases associated with the inflammatory process as well as applications for the diagnosis of disease.

Other References

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