U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method of treating a viral infection by administering a steroid compound

Patent 5763430 Issued on June 9, 1998. Estimated Expiration Date: Icon_subject June 9, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3016390

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Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments
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Inventor

Assignee

Application

No. 479457 filed on 06/07/1995

US Classes:

514/169, Cyclopentanohydrophenanthrene ring system DOAI514/170, Plural Compounds containing cyclopentanohydrophenanthrene ring systems514/171, With additional active ingredient514/172, Hetero ring containing514/173, Spiro ring system514/174, -O-C-O- is part of a hetero ring (e.g., acetonide, etc.)514/175, -C(=O)-O-is part of a hetero ring (e.g., lactone, etc.)514/176, Nitrogen containing hetero ring514/177, Oxygen double bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/178, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/179, Modified C-ring (except methyl in 13-position) (e.g., double bond containing, substituted, etc.)514/180, 9-position substituted514/181, 21-position substituted514/182Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system

Examiners

Primary: Prior, Kimberly J.

Attorney, Agent or Firm

Foreign Patent References

  • 0394971 EP. 10/12/1990
  • 0466315 EP. 01/12/1992
  • 2361899 FR. 03/12/1978
  • 1565351 GB. 04/12/1980
  • WO 87/02367 WO. 04/12/1987
  • WO 91/19731 WO. 12/12/1991
  • WO 93/25197 WO. 12/12/1993
  • WO 94/20520 WO. 09/12/1994
  • WO 94/19366 WO. 09/12/1994

International Classes

A61K 031/56
A61K 031/565
A61K 031/57
A61K 031/58

Abstract

A method of treating a viral infection includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. This compound treats the viral infection by suppressing the growth of a viral target cell. As one specific example, this compound may be used to treat HIV infection.

Other References

  • Moriarty, R.M., et al., "Synthesis of Squalamine. A Steroidal Antibiotic from the Shark," Tetrahedron Letters, vol. 35, No. 44, 31 Oct. 1994, pp. 8103-8106
  • K.S. Moore et al., "Squalamine: An aminosterol antibiotic from the shark," Proc. Natl. Acad. Sci. USA, vol. 90, Feb. 1993, pp. 1354-1358
  • A.M. Bellini et al., "Antimicrobial Activity of Basic Cholane Derivatives Part IX," Arch. Pharm. (Weinheim), vol. 323, 1990, pp. 201-205
  • A.M. Bellini et al., "Antimicrobial activity of basic cholane derivatives. X," Steroids, vol. 56, Jul. 1991, pp. 395-397
  • J. McKenna et al., "Bis-steroids as Potential Enzyme Models," J.C.S. Chem Comm., 1977, pp. 809-811
  • S.L. Wehrli et al., "Structure of the novel steroidal antibiotic squalamine determined by two-dimensional NMR spectroscopy," Steroids, vol. 58, No. 8, Aug. 1993
  • A. Sadownik et al., "Rapid Constuction of a Squalamine Mimic," Journal of the American Chemical Society, vol. 117, 1995, pp. 6138-6139
  • R. Crum et al., "A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment," Science, vol. 230, Dec. 20, 1985, pp. 1377-1378
  • W. Auerbach et al., "Angiogenesis Inhibition: A Review," Pharmac. Ther., vol. 63, 1994, pp. 265-311
  • A. Gagliardi et al., "Inhibition of Angiogenesis by Antiestrogens," Cancer Research, vol. 53, Feb. 1, 1993, pp. 533-53
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