Method of treating a viral infection by administering a steroid compound
Patent 5763430 Issued on June 9, 1998. Estimated Expiration Date: June 9, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/169, Cyclopentanohydrophenanthrene ring system DOAI514/170, Plural Compounds containing cyclopentanohydrophenanthrene ring systems514/171, With additional active ingredient514/172, Hetero ring containing514/173, Spiro ring system514/174, -O-C-O- is part of a hetero ring (e.g., acetonide, etc.)514/175, -C(=O)-O-is part of a hetero ring (e.g., lactone, etc.)514/176, Nitrogen containing hetero ring514/177, Oxygen double bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/178, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/179, Modified C-ring (except methyl in 13-position) (e.g., double bond containing, substituted, etc.)514/180, 9-position substituted514/181, 21-position substituted514/182Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system
A method of treating a viral infection includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. This compound treats the viral infection by suppressing the growth of a viral target cell. As one specific example, this compound may be used to treat HIV infection.
Other References
Moriarty, R.M., et al., "Synthesis of Squalamine. A Steroidal Antibiotic from the Shark," Tetrahedron Letters, vol. 35, No. 44, 31 Oct. 1994, pp. 8103-8106
K.S. Moore et al., "Squalamine: An aminosterol antibiotic from the shark," Proc. Natl. Acad. Sci. USA, vol. 90, Feb. 1993, pp. 1354-1358
A.M. Bellini et al., "Antimicrobial Activity of Basic Cholane Derivatives Part IX," Arch. Pharm. (Weinheim), vol. 323, 1990, pp. 201-205
A.M. Bellini et al., "Antimicrobial activity of basic cholane derivatives. X," Steroids, vol. 56, Jul. 1991, pp. 395-397
J. McKenna et al., "Bis-steroids as Potential Enzyme Models," J.C.S. Chem Comm., 1977, pp. 809-811
S.L. Wehrli et al., "Structure of the novel steroidal antibiotic squalamine determined by two-dimensional NMR spectroscopy," Steroids, vol. 58, No. 8, Aug. 1993
A. Sadownik et al., "Rapid Constuction of a Squalamine Mimic," Journal of the American Chemical Society, vol. 117, 1995, pp. 6138-6139
R. Crum et al., "A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment," Science, vol. 230, Dec. 20, 1985, pp. 1377-1378
W. Auerbach et al., "Angiogenesis Inhibition: A Review," Pharmac. Ther., vol. 63, 1994, pp. 265-311
A. Gagliardi et al., "Inhibition of Angiogenesis by Antiestrogens," Cancer Research, vol. 53, Feb. 1, 1993, pp. 533-53