U.S. patents available from 1976 to present.
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Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof

Patent 5762961 Issued on June 9, 1998. Estimated Expiration Date: Icon_subject February 9, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3557717

3619294

3632357

3655442

Stabilizers for reconstituted, lyophilized samples
Patent #: 4127502
Issued on: 11/28/1978
Inventor: Li Mutti ,   et al.

Process for preparing a biological composition for use as a reference control in diagnostic analysis
Patent #: 4158544
Issued on: 06/19/1979
Inventor: Louderback

Compressed chewable antacid tablet and method for forming same
Patent #: 4327076
Issued on: 04/27/1982
Inventor: Puglia ,   et al.

Compressed chewable antacid tablet and method for forming same
Patent #: 4327077
Issued on: 04/27/1982
Inventor: Puglia ,   et al.

Method of forming an aqueous solution of 3-3-Bis(p-hydroxyphenyl)-phthalide
Patent #: 4588744
Issued on: 05/13/1986
Inventor: McHugh

Trehalose as stabilizer and tableting excipient
Patent #: 4678812
Issued on: 07/07/1987
Inventor: Bollin, Jr. ,   et al.

More ...

Inventors

Assignee

Application

No. 599277 filed on 02/09/1996

US Classes:

424/464, Tablets, lozenges, or pills424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/468, Sustained or differential release type424/489Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)

Examiners

Primary: Page, Thurman K.
Assistant: Howard, Sharon

Attorney, Agent or Firm

Foreign Patent References

  • 0415567 EP. 03/13/1991
  • 606 753 EP. 07/13/1994
  • 636 693 EP. 02/13/1995
  • 0714905 EP. 06/13/1996
  • 58-216695 JP. 12/13/1983
  • 9977 GB. 06/13/2012
  • 1 381 588 GB. 01/13/1975
  • 1381588 GB. 01/13/1975
  • 2206273 GB. 01/13/1989
  • WO 87/00196 WO. 01/13/1987
  • 87/00196 WO. 01/13/1987
  • WO 89/06542 WO. 07/13/1989
  • WO 92/02133 WO. 02/13/1992
  • WO 93/02834 WO. 02/13/1993
  • 93/10758 WO. 06/13/1993
  • 93/11220 WO. 06/13/1993
  • 95/06126 WO. 03/13/1995
  • WO 95/33488 WO. 12/13/1995

International Classes

A61K 009/20
A61K 009/22

Abstract

The invention provides methods of making rapidly soluble tablets of decreased weight compared to similar solid tablets. The invention further provides novel, rapidly soluble tablets of decreased weight compared to similar solid tablets. The tablets offer increased rates of dissolution and disintegration.

Other References

  • Dialog.RTM. English Abstract of JP 58-216695 (Dec. 16, 1983)
  • Dialog.RTM. WPI File 351 Abstract of PCT WO 87/05300 (Sep. 11, 1987)
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  • Vromans et al., "Studies on tableting properties of lactose. Part 2. Consolidation and compaction of different types of crystalline lactose" Pharm. Weekbl ›Sci! (1985) 7:186-193
  • De Boer et al., "Studies on tableting properties of lactose. Part III. The consolidation behaviour of sieve fractions of crystalline ଱-lactose monohydrate" Pharm Weekbl ›Sci! (1986) 8:145-150
  • Van Kamp et al., "Studies on tableting properties of lactose. V. Effects of both lubrication and addition of disintegrants on properties of tablets prepared from different types of crystalline lactose" Acta Pharm. Suec. (1986) 23:217-230
  • Vromans et al., "Studies on tableting properties of lactose. VI. Consolidation and compaction of spray dried amorphous lactose" Acta Pharm. Suec. (1986) 23:231-240
  • Georgakopoulos et al., "The effects of using different grades of PVP and gelatin as binders in the fluidized bed granulation and tableting of lactose" Pharmazie (1983) 38:240-243
  • York et al., "Science Papers. The tensile strength and compression behaviour of lactose, four fatty acids, and their mixtures in relation to tableting" J. Pharm. Pharmac. (1973) 25:Suppl:1P-11P
  • Blakely et al., "Dry instant blood typing plate for bedside use" Lancet (1990) 336:854-855
  • Roser, "Trehalose, a new approach to premium dried foods" Trends in Food Sci. and Tech. (Jul. 1991) pp. 166-169
  • Colaco et al., "Trehalose stabilisation of biological molecules" Biotechnol. Internat. (1992) pp. 345-350
  • Roser, "Trehalose dyring: A novel replacement of freeze-drying" BioPharm. (1991) 4:47-53
  • Colaco et al., "Extraordinary stability of enzymes dried in trehalose: Simplified molecular biology" BioTech. (1992) 10:1007-1011
  • Roser et al., "A sweeter way to fresher food" New Scientist (May 1993) pp. 25-28
  • Madzarovova-Nohejlova, "Trehalase deficiency in a family" Gastroenterol. (1973) 65:130-13
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