Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
Patent 5756736 Issued on May 26, 1998. Estimated Expiration Date: 
January 26, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 26, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent Antiviral compounds Patent #: 5043339 InventorsApplicationNo. 592283 filed on 01/26/1996US Classes:544/276Nitrogen attached directly or indirectly to the purine ring system by nonionic bondingExaminersPrimary: Berch, Mark L.Attorney, Agent or FirmForeign Patent References
International ClassC07D 473/18AbstractProcess for preparing the L-monovaline ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts. The present process provides an N,O-bis-trityl intermediate of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol which allows for mono-esterification by an L-valine derivative. These products are of value as antiviral agents with improved absorption.Other References
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