U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method of preparing controlled-release preparations for biologically active materials and resulting compositions

Patent 5753259 Issued on May 19, 1998. Estimated Expiration Date: Icon_subject May 19, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method of enhancing the administration of pharmalogically active agents
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Method of preparing a controlled-release pharmaceutical preparation, and resulting composition
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Inventor: Geho

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Inventors

Assignee

Application

No. 313543 filed on 09/27/1994

US Classes:

424/50, Ferment containing (e.g., enzymes, bacteria, etc.)264/4.1, Liquid encapsulation utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)264/4.3, With treatment subsequent to solid wall formation (e.g., coating, hardening, etc.)264/4.6Solid-walled microcapsule formed by physically removing a constituent (e.g., evaporation, extraction, etc.)

Examiners

Primary: Kishore, Gollamudi S.

Attorney, Agent or Firm

Foreign Patent References

  • 0041772 EP. 01/11/1981
  • 65/26837 JP. 11/11/1965
  • 2069133 GB 08/11/1981

International Class

A61K 009/127

Foreign Application Priority Data

1982-11-26 SE

Abstract

A method and product for preparing a controlled-release composition are provided. The method comprises formation of a mixture containing at least one amphiphilic substance capable of forming a liquid crystalline phase, in contact with a liquid selected from the group consisting of water, glycerol, ethylene glycol, propylene glycol and mixtures thereof. The method includes a step of providing in such mixture a bioactive material.

Other References

  • Gregoriadis: "The Carrier Potential of Liposomes in Biology and Medicine", The New England Journal of Medicine, vol. 295, No. 13, pp. 704-710, Sep. 23, 1976
  • First page from The Journal of Physical Chemistry, 1988 92, 2261
  • F. Gstirner, Grundstoffe and Verfahren der Arzneibereitung, Ferdinand Enke Verlag, Stuttgart, 1960, pp. 454-455
  • S.G. Frank, Acta Pharm. Suec. 13, 41-42 (1976)
  • Linstrom et al "Aqueous Lipid Phases of Relevance to Intestinal Fat Digestion and Absorption", Lipids, vol. 16, No. 10, Oct. 1981, pp. 749-754
  • Svard et al "Micelles, Vesicles and Liquid Crystals in the Monoolein--Sodium Taurocholate--Water System"
  • Ulmius et al "Molecular Organization in the Liquid-Crystalline Phases of Lecithin-Sodium Cholate-Water Systems . . . " Biochemistry 1982, 1553-1560, Surfactants in Solution, vol. 1
  • Edited by K.L. Mittal et al, Plenum Publ. Corp. (1984) pp. 143-152. Gutman et al "31p and 2H NMR Studies . . .
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