Patent 5753251 Issued on May 19, 1998. Estimated Expiration Date: June 2, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/426, Errodable, resorbable, or dissolving106/1.05, Metal-depositing composition or substrate-sensitizing compositions for metal-depositing compositions106/1.13, Elemental metal is Group IB (Cu, Ag, Au)106/1.14, Elemental metal is Ag106/1.15, Elemental metal is noble metal of Group VIII (Ru, Rh, Pd, Os, Ir, Pt)106/1.16, Elemental metal is Group IIB (Zn, Cd, Hg) metal106/1.17, Elemental metal is Zn106/1.18, Metal-depositing composition contains elemental metal of Group IB (Cu, Ag, Au)106/1.19, Elemental metal is Ag106/1.21, Metal composition contains elemental noble metal of Group VIII (Ru, Rh, Pd, Os, Ir, Pt)106/723, Process involving steam, electrical, magnetic or wave energy, vibration or vacuum or product thereof106/733, Titanium, vanadium, chromium, molybdenum, tungsten, manganese, iron, copper, zinc, tin or lead compound containing (Ti, V, Cr, Mo, W, Mn, Fe, Cu, Zn, Sn, Pb)427/248.1, COATING BY VAPOR, GAS, OR SMOKE427/250Metal coating
Anti-microbial coatings and method of forming same on medical devices are provided. The coatings are formed by depositing a biocompatible metal by vapor deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by mechanical working to produce atomic disorder are also provided. The invention extends to other metal coatings and powders similarly formed so as to provide enhanced solubility.
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