Methods and apparatus for image-guided ultrasound delivery of compounds through the blood-brain barrier
August 21, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3499437 Cancer treatment Method and apparatus for selective cell destruction Process for applying a localized magnetic or electric field Method for diagnostically imaging lesions in the brain inside a blood-brain barrier Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability Magnetic resonance surgery using heat waves produced with focussed ultrasound Thrombus resolving treatment apparatus Manually positioned focussed energy system guided by medical imaging Solid tumor, cortical function, and nerve tissue imaging methods and device InventorsAssigneeApplicationNo. 711289 filed on 08/21/1996US Classes:600/458, Contrast enhancement600/411, Combined with therapeutic or diverse diagnostic device600/437, Ultrasonic604/22With means for cutting, scarifying, or vibrating (e.g., ultrasonic, etc.) tissueExaminersPrimary: Lateef, Marvin M.Assistant: Shaw, Shawna J. Attorney, Agent or FirmInternational ClassA61B 005/00AbstractImage-guide methods and apparatus for ultrasound delivery of compounds through the blood-brain barrier to selected locations in the brain target a selected location in the brain and applying ultrasound to effect in the tissues and/or fluids at that location a change detectable by imaging. At least a portion of the brain in the vicinity of the selected location is imaged, e.g., via magnetic resonance imaging, to confirm the location of that change. A compound, e.g., a neuropharmaceutical, in the patient's bloodstream is delivered to the confirmed location by applying ultrasound to effect opening of the blood-brain barrier at that location and, thereby, to induce uptake of the compound there.Other References
Field of SearchMethodsUltrasonic Hyperthermia Contact-free comminution of concretion Magnetic imaging agent (e.g., NMR, MRI, MRS, etc.) With means for cutting, scarifying, or vibrating (e.g., ultrasonic, etc.) tissue CONTROLLED RELEASE THERAPEUTIC DEVICE OR SYSTEM Osmotic or diffusion pumped device or system | |
