U.S. patents available from 1976 to present.
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Arrays of materials attached to a substrate

Patent 5744305 Issued on April 28, 1998. Estimated Expiration Date: Icon_subject June 6, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Photoresponsive redox detection and discrimination
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Coupling of nucleic acids to solid support by photochemical methods
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Inventors

Application

No. 466632 filed on 06/06/1995

US Classes:

435/6, Involving nucleic acid435/7.92, Heterogeneous or solid phase assay system (e.g., ELISA, etc.)435/7.94, Sandwich assay435/7.95, Indirect assay435/969, MULTIPLE LAYERING OF REACTANTS435/973, SIMULTANEOUS DETERMINATION OF MORE THAN ONE ANALYTE436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/527, Glass or silica436/807, APPARATUS INCLUDED IN PROCESS CLAIM (E.G., PHYSICAL SUPPORT STRUCTURES, ETC.)436/809, Multifield plates or multicontainer arrays530/334, Polymer supported synthesis, e.g., solid phase synthesis, Merrifield synthesis, etc.536/24.3, Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA536/25.3, Synthesis of polynucleotides or oligonucleotides536/25.32Labels or markers utilized (e.g., radiotracer, affinity, fluoroescent, phosphorescent, markers, etc.)

Examiners

Primary: Zitomer, Stephanie W.
Assistant: Tran, Pablo N.

Attorney, Agent or Firm

Foreign Patent References

  • 0 046 083 EP 02/13/1982
  • 0 103 197 EP 03/13/1984
  • 0 228 310 EP. 10/13/1988
  • 0 328 256 A1 EP 01/13/1989
  • 0 392 546 EP 10/13/1990
  • 1-233 447 JP. 09/13/1989
  • 2 196 476 GB 02/13/1990
  • WO 84/03564 WO 09/13/1984
  • WO 86/06487 WO 11/13/1986
  • WO 89/11548 WO 11/13/1989
  • WO 89/10977 WO 11/13/1989
  • WO 90/03382 WO 04/13/1990
  • WO 90/04652 WO 05/13/1990
  • WO 90/15070 WO 12/13/1990
  • WO 91/07087 WO 05/13/1991

International Classes

C12Q 001/68
C07H 021/04
C07H 021/02

Abstract

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

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