Patent 5744305 Issued on April 28, 1998. Estimated Expiration Date: June 6, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
435/6, Involving nucleic acid435/7.92, Heterogeneous or solid phase assay system (e.g., ELISA, etc.)435/7.94, Sandwich assay435/7.95, Indirect assay435/969, MULTIPLE LAYERING OF REACTANTS435/973, SIMULTANEOUS DETERMINATION OF MORE THAN ONE ANALYTE436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/527, Glass or silica436/807, APPARATUS INCLUDED IN PROCESS CLAIM (E.G., PHYSICAL SUPPORT STRUCTURES, ETC.)436/809, Multifield plates or multicontainer arrays530/334, Polymer supported synthesis, e.g., solid phase synthesis, Merrifield synthesis, etc.536/24.3, Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA536/25.3, Synthesis of polynucleotides or oligonucleotides536/25.32Labels or markers utilized (e.g., radiotracer, affinity, fluoroescent, phosphorescent, markers, etc.)
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
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