16-substituted-6-aza-androsten-4-ene-3-ones as 5--reductase inhibitors
October 17, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3193554 Heterocyclic inhibitors of 5--testosterone reductase 17 yl 6 azaandrost-4,6 diazo-4-ene-3-ones Method of treating small mouth ulcers Synthesis of 6-azaandrostenones Combination method of treating acne using 4-AZA-5-cholestan-ones and 4-AZA-5-androstan-ones as selective 5-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents 5547957 Methods of treating androgenic alopecia with finasteride [17ଲ-N-mono-substituted-carbamoyl-4-aza-5--androst-1-en-ones] Methods of treating androgenic alopecia with finasteride [17ଲ-N-mono-substituted-carbamoyl-4-aza-5--androst-1-en-ones] Stimulation of hair growth with minoxidil and a 5-reductase inhibitor Patent #: 5578599 InventorsAssigneeApplicationNo. 732953 filed on 10/17/1996US Classes:514/284, Tetracyclo ring system having the six-membered hetero ring as one of the cyclos514/253.02, Polycyclo ring system having the additional six-membered nitrogen hetero ring as one of the cyclos514/256, 1,3-diazines (e.g., pyrimidines, etc.)514/263.22, The additional hetero ring is six-membered consisting of one nitrogen and five carbons514/269, Pyrimidines with chalcogen bonded directly to a ring carbon of said pyrimidine moiety540/4, Boron or silicon containing544/264, Purines (including hydrogenated)544/265, Chalcogen bonded directly to ring carbon of the purine ring system544/298, Chalcogen bonded directly to diazine ring carbon546/14, Silicon containing546/61Tetracyclo ring system having the six-membered hetero ring as one of the cyclosExaminersPrimary: Daus, Donald G.Attorney, Agent or FirmForeign Patent References
International ClassA61K 031/715AbstractCompounds of the formula I ##STR1## are inhibitors of 5-reductase, and are useful for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern baldness, prostatic carcinoma, prostatitis and benign prostatic hyperplasia.Other References
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